{"id":"W3158369402","doi":"10.1039/d1md00046b","title":"Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties","year":2021,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Chemistry; Butyrylcholinesterase; Acetylcholinesterase; Antioxidant; Cholinesterase; Ferulic acid; Biochemistry; Cardanol; Pharmacology; Reactive oxygen species; Aché; Enzyme; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628115,0.00045626,0.000231264,0.0003422696,0.0001069703,0.0003236379,0.0002311196,0.0003173511,0.001588265],"category_scores_gemma":[0.0001200979,0.0001008343,0.0001668428,0.0001623246,0.0001385504,0.0002764975,0.0002282354,0.0004909589,0.0005096751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885025,"about_ca_system_score_gemma":0.0002379556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003077888,"about_ca_topic_score_gemma":0.001155823,"domain_scores_codex":[0.999966,0.000005411629,0.000002404515,0.00000700409,0.00001015697,0.000008989287],"domain_scores_gemma":[0.9999664,0.000004187491,0.000009091646,0.00000239833,0.000009880764,0.000008129152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162264,0.0001553046,0.0002908495,0.0004851513,0.00003215895,0.0002441758,0.00002675689,0.0004036834,0.9648309,0.0009599229,0.0006237021,0.0317851],"study_design_scores_gemma":[0.00009556917,0.0009452925,0.001138262,0.00004365014,0.0000431189,0.0002693051,0.00001867277,0.0008247906,0.9716477,0.0001921112,0.02476765,0.00001382825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8928614,0.0395071,0.03716458,0.001277912,0.0003178154,0.0008284084,0.002726168,0.0004835982,0.02483302],"genre_scores_gemma":[0.963577,0.01195538,0.01541076,0.0004668723,0.00003351113,0.000133624,0.0009561762,0.00002000047,0.007446456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588265,"threshold_uncertainty_score":0.005313218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636696390251689,"score_gpt":0.2536886847579114,"score_spread":0.2373217208553945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}