{"id":"W3158387193","doi":"","title":"MECHANISMS OF IMINE-BASED INHIBITORS OF DAHP SYNTHASE, AN ANTIMICROBIAL TARGET.","year":2018,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Antimicrobial; Chemistry; Imine; ATP synthase; Biochemistry; Pharmacology; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008138009,0.0003413983,0.0004583956,0.0001545019,0.00007741735,0.00001574028,0.0003967508,0.0004527626,0.00527642],"category_scores_gemma":[0.00001772023,0.0003534389,0.0002756874,0.0001813264,0.0001213967,0.00001667125,0.00006628255,0.0001068543,0.000003372865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001730053,"about_ca_system_score_gemma":0.0002056509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001265938,"about_ca_topic_score_gemma":0.0003674162,"domain_scores_codex":[0.9987367,0.00007414872,0.0002998916,0.0004645521,0.0001842718,0.0002403767],"domain_scores_gemma":[0.9988308,0.00001265142,0.0004648273,0.0003696996,0.0002396526,0.00008236315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008892228,0.0002950726,0.0001072396,0.0004396875,0.0001403951,0.000006976536,0.00009315986,0.00003228906,0.9835782,0.0002733073,0.0008208965,0.01332353],"study_design_scores_gemma":[0.0005967034,0.000530801,0.0001491651,0.0002303143,0.000142555,0.000001133978,0.001124618,0.00004877355,0.947323,0.00004950789,0.04943028,0.000373165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8748548,0.0001676773,0.00245355,0.00002433669,0.0009294424,0.0003680638,0.0005970501,0.00002779519,0.1205773],"genre_scores_gemma":[0.9087115,0.00003644263,0.003254775,0.00004701841,0.0002706062,0.000001185002,0.001539762,0.00007261083,0.08606608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04860938,"threshold_uncertainty_score":0.9998918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008113082075795912,"score_gpt":0.2021805160199282,"score_spread":0.1940674339441323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}