{"id":"W3158404933","doi":"10.1021/acs.jmedchem.0c02200","title":"Pharmacological Targeting of Executioner Proteins: Controlling Life and Death","year":2021,"lang":"en","type":"review","venue":"Journal of Medicinal Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Small molecule; Apoptosis; Chemistry; Bcl-2 family; Cell biology; Cancer research; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002793965,0.0007238614,0.0008200395,0.001427034,0.000179042,0.0006535791,0.0006691078,0.0006050183,0.002264169],"category_scores_gemma":[0.0002174982,0.0002491703,0.000375779,0.0009696073,0.0003693802,0.000836121,0.0004589696,0.001494401,0.001645833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004279809,"about_ca_system_score_gemma":0.00035122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003718072,"about_ca_topic_score_gemma":0.0007283388,"domain_scores_codex":[0.9999021,0.00001402715,0.000009244499,0.00002021313,0.00003912798,0.00001519699],"domain_scores_gemma":[0.9999286,0.00002551959,0.00001541398,0.000003581687,0.00001629545,0.00001062041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001455342,0.0001745678,0.0001399546,0.01234026,0.00007773654,0.0002318723,0.00005162567,0.0006522291,0.02097886,0.007362195,0.01440737,0.9434379],"study_design_scores_gemma":[0.00004364215,0.0003642965,0.0007186996,0.001003393,0.00007952545,0.001158538,0.00002820897,0.0002287544,0.007089419,0.002147006,0.9871126,0.00002586871],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008713237,0.995514,0.0006231219,0.0002080613,0.0002093538,0.00001704275,0.00004786436,0.00002924765,0.002479913],"genre_scores_gemma":[0.003743328,0.993622,0.0004649299,0.000224969,0.0001019073,0.00001760917,0.0000716221,0.000003436622,0.001750238],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002264169,"threshold_uncertainty_score":0.007574439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915517455494045,"score_gpt":0.3219057387724661,"score_spread":0.2927505642175257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}