{"id":"W3158447546","doi":"10.1016/j.ejmech.2021.113496","title":"Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Chemistry; LNCaP; DU145; Androstenedione; Dimer; Cyproterone acetate; Stereochemistry; Androgen; Testosterone (patch); Dihydrotestosterone; Prostate cancer; Internal medicine; Endocrinology; Biochemistry; Hormone; Organic chemistry; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975236,0.0002982077,0.0002455974,0.0001360799,0.0001643092,0.0001857609,0.0004345303,0.0002352374,0.001707819],"category_scores_gemma":[0.0001547294,0.0001251727,0.0002397518,0.0001966257,0.0001282834,0.0001347674,0.0001429056,0.0004083962,0.0005650389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240121,"about_ca_system_score_gemma":0.0003154369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005472406,"about_ca_topic_score_gemma":0.001135909,"domain_scores_codex":[0.9998641,0.00003918863,0.000009287438,0.00003146472,0.00003347087,0.00002243574],"domain_scores_gemma":[0.9999355,0.00000658924,0.00001495547,0.000008454525,0.0000150612,0.00001956523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005422513,0.0001873159,0.0002238914,0.0001757966,0.00002097039,0.0001392681,0.00005624442,0.001189734,0.9840564,0.0006689227,0.0005483126,0.01219097],"study_design_scores_gemma":[0.0001284978,0.002104326,0.000711795,0.000007125067,0.00003248826,0.0004075129,0.00004313372,0.001243867,0.9829402,0.0001119415,0.01224989,0.00001917767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602526,0.007261865,0.02367331,0.0003651348,0.0001975262,0.0003162859,0.001182568,0.0001987719,0.006551913],"genre_scores_gemma":[0.9730013,0.003440198,0.01420253,0.0002159484,0.00003593953,0.0001051241,0.0009502468,0.00002779916,0.008020901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707819,"threshold_uncertainty_score":0.005713224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0753581297433195,"score_gpt":0.3165685419137277,"score_spread":0.2412104121704082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}