{"id":"W3158466154","doi":"10.1242/jcs.248559","title":"Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation","year":2021,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Lamin; Mechanotransduction; Biology; Nucleus; Inner membrane; Nuclear lamina; Biophysics; Deformation (meteorology); Stiffness; Envelope (radar); Cell biology; Nuclear protein; Physics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290925,0.00003869671,0.00006374652,0.00002309981,0.00004983027,0.000021381,0.00007057996,0.00003544616,0.000008473284],"category_scores_gemma":[0.0001017745,0.00003099259,0.00002376249,0.00009943599,0.0001087965,0.00001838864,0.00003928542,0.00004019238,4.771633e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007833263,"about_ca_system_score_gemma":0.00007557718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002396562,"about_ca_topic_score_gemma":0.000005800236,"domain_scores_codex":[0.9995499,0.00001423026,0.0001504673,0.00006876935,0.0001488367,0.00006775346],"domain_scores_gemma":[0.9994583,0.000005146246,0.0001711683,0.00006391892,0.0002590225,0.00004245376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003643639,0.00001501884,0.0009846048,0.00001252844,0.000002218274,0.000002297287,0.0000377888,0.00001549996,0.994469,0.00001572803,0.00004634056,0.004362509],"study_design_scores_gemma":[0.0003589796,0.0001731709,0.1464526,0.00001725103,0.00001358493,0.00009258249,0.0001708412,0.0004639672,0.8488906,0.00003184531,0.003277851,0.00005672623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987006,0.00008016536,0.0008199378,0.00003523617,0.0001753458,0.00001513211,0.00001256947,8.459812e-7,0.0001601578],"genre_scores_gemma":[0.9995708,0.00008416184,0.0002093558,0.00001789604,0.00008002765,6.229541e-8,0.00001652501,0.000002313924,0.00001888142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1455784,"threshold_uncertainty_score":0.1263841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003507159052202829,"score_gpt":0.2022379786250052,"score_spread":0.1987308195728024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}