{"id":"W3158468209","doi":"10.1084/jem.20210446","title":"SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?","year":2021,"lang":"en","type":"review","venue":"The Journal of Experimental Medicine","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Human Genome Research Institute; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Institutes of Health; SCOR Corporate Foundation for Science; National Health and Medical Research Council; Novo Nordisk Fonden; Fondation pour la Recherche Médicale; Agencia Estatal de Investigación; Yale University; University of New South Wales; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Université de Paris; Imperial College Healthcare NHS Trust; Imperial College London; Rockefeller University; UK Research and Innovation; Ministerio de Ciencia e Innovación; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; Burroughs Wellcome Fund; Fondation du Souffle; American Academy of Allergy Asthma and Immunology; Michael Smith Health Research BC; St. Giles Foundation; National Center for Advancing Translational Sciences; Medical Research Council; Howard Hughes Medical Institute","keywords":"Kawasaki disease; Pathogenesis; Disease; Immunology; Immune system; Immunity; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Viral pathogenesis; Viral infection; Virology; Medicine; Virus; Infectious disease (medical specialty); Viral replication; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002913213,0.0003556681,0.001580201,0.0001896389,0.0001162479,0.000009701291,0.0004207466,0.00007877628,0.0001600031],"category_scores_gemma":[0.00015836,0.0001642618,0.0003791403,0.0003850664,0.0003601871,0.00004138257,0.0001252918,0.0004201478,0.00001255637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001010883,"about_ca_system_score_gemma":0.0004462446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003049528,"about_ca_topic_score_gemma":0.000001832927,"domain_scores_codex":[0.997482,0.0003275517,0.001181442,0.0002009156,0.0005909793,0.000217095],"domain_scores_gemma":[0.9978697,0.0002767844,0.0007063442,0.0006613542,0.0001815885,0.0003042271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002515108,0.005224323,0.000417508,0.01674221,0.01280645,0.003549187,0.02073984,0.00001312858,0.07955363,0.001765379,0.159184,0.6974892],"study_design_scores_gemma":[0.00213365,0.002528265,0.001402242,0.0434099,0.01308428,0.007035081,0.002423979,0.00001011455,0.001434199,0.00006270612,0.9261059,0.0003697396],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01652058,0.9789764,0.00001523552,0.003040283,0.0002700248,0.0008218588,0.0000211767,0.000007911615,0.0003264846],"genre_scores_gemma":[0.04283436,0.9551797,0.00006811485,0.001060377,0.0005659423,0.00003395155,0.00002419582,0.000049534,0.0001838582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7669218,"threshold_uncertainty_score":0.66984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06919893776327797,"score_gpt":0.3979657451293051,"score_spread":0.3287668073660271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}