{"id":"W3158468209","doi":"10.1084/jem.20210446","title":"SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?","year":2021,"lang":"en","type":"review","venue":"The Journal of Experimental Medicine","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Human Genome Research Institute; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Institutes of Health; SCOR Corporate Foundation for Science; National Health and Medical Research Council; Novo Nordisk Fonden; Fondation pour la Recherche Médicale; Agencia Estatal de Investigación; Yale University; University of New South Wales; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Université de Paris; Imperial College Healthcare NHS Trust; Imperial College London; Rockefeller University; UK Research and Innovation; Ministerio de Ciencia e Innovación; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; Burroughs Wellcome Fund; Fondation du Souffle; American Academy of Allergy Asthma and Immunology; Michael Smith Health Research BC; St. Giles Foundation; National Center for Advancing Translational Sciences; Medical Research Council; Howard Hughes Medical Institute","keywords":"Kawasaki disease; Pathogenesis; Disease; Immunology; Immune system; Immunity; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Viral pathogenesis; Viral infection; Virology; Medicine; Virus; Infectious disease (medical specialty); Viral replication; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005464205,0.0007014514,0.001398595,0.002136078,0.0002662381,0.001004751,0.0008874523,0.001291619,0.002713749],"category_scores_gemma":[0.001182292,0.0002472114,0.0004826689,0.001939991,0.0006182701,0.001803604,0.0006413104,0.002306119,0.001463798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006601737,"about_ca_system_score_gemma":0.001372683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274829,"about_ca_topic_score_gemma":0.00190851,"domain_scores_codex":[0.9998184,0.00003430784,0.00003141411,0.0000299545,0.00006250208,0.00002341292],"domain_scores_gemma":[0.9995627,0.0001794142,0.00006234449,0.0000150284,0.0001283254,0.00005217364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001136845,0.0000508486,0.0003146817,0.01740949,0.0001140203,0.0003285555,0.00007529276,0.0002462077,0.0008962529,0.004322203,0.06503998,0.9110887],"study_design_scores_gemma":[0.00002065322,0.00006631045,0.001123484,0.006876874,0.0001183808,0.002472017,0.00009833594,0.00006577341,0.000180152,0.002412844,0.9865458,0.00001939604],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000535537,0.9987171,0.00004427529,0.000560492,0.0003084278,0.000001539446,0.000008676973,0.000004045714,0.0003018902],"genre_scores_gemma":[0.0003486314,0.998786,0.00007332698,0.0002803147,0.0002793318,0.000002299826,0.00001689014,9.085127e-7,0.000212276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002713749,"threshold_uncertainty_score":0.009078383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06919893776327797,"score_gpt":0.3979657451293051,"score_spread":0.3287668073660271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}