{"id":"W3158479017","doi":"10.1016/s0735-1097(21)04450-8","title":"APABETALONE (RVX-208) REDUCES ACE2 PROTEIN ABUNDANCE AND PREVENTS SARS-COV-2 SPIKE PROTEIN BINDING TO HUMAN LUNG CELLS, A MOA THAT COULD ATTENUATE VIRAL ENTRY","year":2021,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Spike Protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Lung; Spike (software development); Cell biology; Virology; Coronavirus disease 2019 (COVID-19); Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009346294,0.0003630471,0.0003878756,0.0001617772,0.0001712574,0.0002701933,0.0002125114,0.0003299215,0.002253521],"category_scores_gemma":[0.0001519649,0.0001137953,0.000244782,0.0001005816,0.0002673502,0.0001919389,0.0001187163,0.0008788556,0.0004653625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764251,"about_ca_system_score_gemma":0.0004085799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106461,"about_ca_topic_score_gemma":0.001662535,"domain_scores_codex":[0.9999179,0.00001439035,0.00000915862,0.000009896013,0.00001502736,0.00003367317],"domain_scores_gemma":[0.9999132,0.00001273288,0.00001438625,0.000009337914,0.000007995081,0.00004225169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003358508,0.000435482,0.0002620893,0.00006891046,0.00001946774,0.0001230651,0.00001702473,0.00009644303,0.9917423,0.0001191999,0.0003533179,0.003404219],"study_design_scores_gemma":[0.0005513258,0.005616121,0.008374902,0.000008969722,0.00004401251,0.0003161222,0.00007608975,0.001294301,0.980903,0.000091241,0.002711447,0.00001250708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960929,0.0009425574,0.0006586226,0.0002679499,0.0001614833,0.00003095908,0.000529444,0.0001458859,0.001170241],"genre_scores_gemma":[0.9950172,0.0005988121,0.0007306791,0.00007276548,0.00003358658,0.00003615568,0.0006630221,0.00001027938,0.002837565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002253521,"threshold_uncertainty_score":0.007538795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119455207026967,"score_gpt":0.3358210215190778,"score_spread":0.3046264694488081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}