{"id":"W3158494926","doi":"10.1111/bcpt.13593","title":"Pharmacogenetic testing to guide therapeutic decision‐making and improve outcomes for children undergoing anthracycline‐based chemotherapy","year":2021,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canada's Michael Smith Genome Sciences Centre; Genome Canada","keywords":"Anthracycline; Pharmacogenetics; Medicine; Chemotherapy; Oncology; Intensive care medicine; Internal medicine; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001479944,0.0004148797,0.0004487868,0.00109113,0.0004386676,0.0009759422,0.0004017125,0.0007916326,0.004940214],"category_scores_gemma":[0.008870148,0.0001291916,0.0005164809,0.000643662,0.0003297249,0.0008860764,0.0008865594,0.002374783,0.0009617254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000832843,"about_ca_system_score_gemma":0.001559888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00291333,"about_ca_topic_score_gemma":0.004678937,"domain_scores_codex":[0.9991196,0.000440685,0.0001009592,0.00008566892,0.0001590312,0.00009405499],"domain_scores_gemma":[0.9979199,0.001039567,0.0003418652,0.0000894468,0.0003278746,0.0002814443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004604271,0.0004384737,0.5397016,0.0003668292,0.0001234999,0.01040951,0.001198344,0.004433411,0.002594183,0.006662683,0.04162676,0.3919842],"study_design_scores_gemma":[0.0002912928,0.001698522,0.5468332,0.007338429,0.0007063954,0.04726576,0.004091441,0.03199485,0.01265258,0.06687442,0.2800014,0.0002517095],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5978209,0.07294746,0.1029405,0.1175604,0.002191132,0.001175822,0.005175933,0.00155409,0.09863371],"genre_scores_gemma":[0.9150679,0.01876507,0.05347751,0.006340759,0.0008336499,0.0002891895,0.001397081,0.0001814191,0.003647491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004940214,"threshold_uncertainty_score":0.01652664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0633703605367876,"score_gpt":0.4445085079519594,"score_spread":0.3811381474151718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}