{"id":"W3158563321","doi":"10.1210/jendso/bvab048.1332","title":"Single Nucleus Transcriptome and Chromatin Accessibility Landscapes of Human Pituitaries","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Transcriptome; Cell type; Chromatin; SOX2; SMARCA4; Gene; LGR5; Cell; Genetics; Gene expression; Internal medicine; Wnt signaling pathway; Transcription factor; Chromatin remodeling; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525336,0.00009949438,0.000208461,0.00000803721,0.0001023805,0.00002795394,0.0001974984,0.00005133387,0.00002152633],"category_scores_gemma":[0.00005914092,0.00006924278,0.0003474929,0.00006876022,0.0001181363,0.000009732077,0.00006819193,0.0001391443,8.21143e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000120619,"about_ca_system_score_gemma":0.0000696085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000103555,"about_ca_topic_score_gemma":0.0000347223,"domain_scores_codex":[0.9992113,0.00006258091,0.0003323638,0.0001181355,0.0001483286,0.0001273271],"domain_scores_gemma":[0.9993845,0.00001563349,0.0001985247,0.0001893104,0.0001662075,0.00004578606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002518562,0.0001553609,0.01153013,0.00006654755,0.0001136723,0.000002622191,0.0003828081,0.000008434143,0.9863313,0.00002274322,0.0009453053,0.0004159181],"study_design_scores_gemma":[0.001013624,0.000238875,0.01909339,0.00004190723,0.00007147879,0.000112936,0.0004759989,0.00001530392,0.9732163,0.0002881973,0.005340112,0.00009189603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972103,0.001662422,0.0001512471,0.0005073478,0.0002130776,0.00004010102,0.00001440869,0.000002665888,0.0001983845],"genre_scores_gemma":[0.9980872,0.0002276351,0.001134905,0.0001612698,0.0001941748,4.760394e-7,0.000004259111,0.00001075767,0.0001792681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01311499,"threshold_uncertainty_score":0.2823639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408003513654644,"score_gpt":0.2506545523441598,"score_spread":0.2365745172076134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}