{"id":"W3158563321","doi":"10.1210/jendso/bvab048.1332","title":"Single Nucleus Transcriptome and Chromatin Accessibility Landscapes of Human Pituitaries","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Transcriptome; Cell type; Chromatin; SOX2; SMARCA4; Gene; LGR5; Cell; Genetics; Gene expression; Internal medicine; Wnt signaling pathway; Transcription factor; Chromatin remodeling; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169829,0.0001286768,0.0002586623,0.000415069,0.0002705679,0.0003294572,0.0001415732,0.0001827293,0.001922382],"category_scores_gemma":[0.0003588514,0.0001268932,0.0002184534,0.0004317714,0.0002276143,0.0001237561,0.0004395003,0.0001317572,0.0005090864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766434,"about_ca_system_score_gemma":0.000202652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004262673,"about_ca_topic_score_gemma":0.008376095,"domain_scores_codex":[0.9998782,0.000009148986,0.000006182607,0.00005826632,0.00002894295,0.00001918567],"domain_scores_gemma":[0.9998641,0.00003697137,0.0000225726,0.00001892037,0.00003677168,0.00002060697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001747834,0.00002497632,0.2300938,0.0003718227,0.0002606984,0.001566827,0.001437939,0.001070367,0.7211648,0.0004485363,0.002797085,0.03901535],"study_design_scores_gemma":[0.00003218307,0.0002253791,0.9028274,0.00005533723,0.000160972,0.004562961,0.001053551,0.003478204,0.07154065,0.0005764579,0.01544302,0.00004380321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832607,0.001416445,0.004029179,0.00004876887,0.00001264833,0.00001869387,0.01012423,0.0001073927,0.000981949],"genre_scores_gemma":[0.9779921,0.0005603411,0.003463272,0.00006549979,0.00001106429,0.00004491631,0.01633854,0.00007049863,0.001453756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004262673,"threshold_uncertainty_score":0.008475721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408003513654644,"score_gpt":0.2506545523441598,"score_spread":0.2365745172076134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}