{"id":"W3158611454","doi":"10.3389/fcell.2021.660069","title":"Zebrafish Cancer Predisposition Models","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Zebrafish; Cancer; Carcinogenesis; Biology; Germline mutation; Genetic screen; Genetic testing; Bioinformatics; Genetic predisposition; Germline; Familial adenomatous polyposis; Cancer research; Genetics; Mutation; Phenotype; Medicine; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001253751,0.0002766922,0.0006442098,0.0001100237,0.00005173942,0.00001853703,0.0001213763,0.000580803,0.00001478541],"category_scores_gemma":[0.00001012654,0.000253485,0.0001098393,0.0001164362,0.00007082723,0.000003558507,0.0001721079,0.000147242,0.000001926291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006426642,"about_ca_system_score_gemma":0.0002805176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001838302,"about_ca_topic_score_gemma":0.00002037934,"domain_scores_codex":[0.9986415,0.0001329325,0.0003672046,0.000563078,0.00004970192,0.0002456193],"domain_scores_gemma":[0.9996506,0.00001128223,0.000120692,0.0001237285,0.00002743397,0.00006626763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007325187,0.00004757156,0.000488626,0.001070799,0.00008790834,0.00000507582,0.0000430573,0.000007249178,0.001026883,0.00001935274,0.003090664,0.9941055],"study_design_scores_gemma":[0.0002115109,0.0000477862,0.00001783168,0.0005489734,0.00006212926,0.00000438538,0.00004289347,0.00001796757,0.001302792,0.0002758389,0.9971123,0.0003555375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007100042,0.9938684,0.002600196,0.000005654502,0.0007041652,0.0002722008,0.00009394768,0.000005343179,0.001740066],"genre_scores_gemma":[0.0002421703,0.9896463,0.007030718,0.000041004,0.00012526,0.0001238693,0.002269027,0.00002779433,0.0004938322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9940217,"threshold_uncertainty_score":0.9999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204706248252394,"score_gpt":0.2854513930967888,"score_spread":0.2634043306142649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}