{"id":"W3158657129","doi":"10.1016/j.jad.2021.04.017","title":"Psychiatric Safety and Weight Loss Efficacy of Naltrexone/bupropion as Add-on to Antidepressant Therapy in Patients with Obesity or Overweight","year":2021,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bausch Health (Canada); University of Waterloo; University of Toronto","funders":"Bausch Health; Orexigen Therapeutics","keywords":"Bupropion; Placebo; Overweight; Medicine; Antidepressant; Weight loss; Discontinuation; Internal medicine; Naltrexone; Depression (economics); Obesity; Adverse effect; Major depressive disorder; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322701,0.0001646122,0.0004586019,0.0002311671,0.00005612861,0.000004403522,0.0000539017,0.00006980266,0.0001045393],"category_scores_gemma":[0.0001008484,0.00009955526,0.00008996283,0.0004008038,0.00005875996,0.00008726463,0.00002079744,0.0002617462,0.000002662762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029222,"about_ca_system_score_gemma":0.0001898597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003171837,"about_ca_topic_score_gemma":0.0001095937,"domain_scores_codex":[0.9989026,0.0001661917,0.00028122,0.0001981975,0.000285417,0.0001663391],"domain_scores_gemma":[0.9991019,0.0002242698,0.0002222194,0.000117346,0.0002052135,0.0001290866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03225599,0.005878179,0.945022,0.00004029174,0.0004077024,0.0001448424,0.000417459,0.00005796408,0.0002647047,0.00002306768,0.0001753969,0.01531234],"study_design_scores_gemma":[0.02287398,0.009089499,0.9620959,0.0002105574,0.0001415806,0.0000377676,0.00008948261,0.000003494,0.005001961,0.00006681141,0.0002873492,0.0001016278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976647,0.0006388979,0.00005130484,0.000708601,0.0001421225,0.0005155229,0.00000774771,0.00000415462,0.0002669102],"genre_scores_gemma":[0.9972597,0.00206688,0.0001816268,0.0004016396,0.00003725702,0.000002576277,0.00000472852,0.00001291602,0.00003271835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01707382,"threshold_uncertainty_score":0.4059746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004867795395877922,"score_gpt":0.2708878239287025,"score_spread":0.2660200285328246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}