{"id":"W3158665167","doi":"10.3389/fmolb.2021.626600","title":"Structural Profiling of Bacterial Effectors Reveals Enrichment of Host-Interacting Domains and Motifs","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Effector; Biology; Virulence; Host (biology); Computational biology; Eukaryote; Pathogen; Cell biology; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070938,0.0001301129,0.0001468844,0.0002440903,0.0001193483,0.0001887114,0.0001360422,0.0002362826,0.000489327],"category_scores_gemma":[0.0001641585,0.00008553292,0.0001560041,0.0001844111,0.0001105012,0.0001640587,0.0001505913,0.0003122456,0.0001956066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001664497,"about_ca_system_score_gemma":0.00009863105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002845695,"about_ca_topic_score_gemma":0.0004429695,"domain_scores_codex":[0.9999132,0.00000992591,0.00000553988,0.00002269699,0.00002515653,0.00002354908],"domain_scores_gemma":[0.9998713,0.00002330215,0.00003991564,0.00001192591,0.00002090516,0.00003265705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006975,0.00001873517,0.002284647,0.00001676069,0.000005413212,0.0000406688,0.00001131566,0.0001424737,0.9961252,0.0000545795,0.00002413558,0.001175332],"study_design_scores_gemma":[0.000008525102,0.0003452112,0.09310719,0.000006353554,0.00003147655,0.0007083753,0.00009653939,0.008502219,0.8954487,0.0001247316,0.001609049,0.00001162371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997614,0.0003276145,0.001383601,0.0000299245,0.000002409684,0.000005952722,0.0002613999,0.00002453509,0.0003505511],"genre_scores_gemma":[0.9967781,0.0002006056,0.001746981,0.00003146445,0.00000209332,0.000006235402,0.0007959077,0.00001213839,0.0004264514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000489327,"threshold_uncertainty_score":0.001636982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004401547499215813,"score_gpt":0.2290028954005542,"score_spread":0.2246013479013384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}