{"id":"W3158685742","doi":"10.1097/ccm.0000000000005049","title":"Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III","year":2021,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Intensive Care Unit Cognitive Disorders","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Daiichi Sankyo Europe; National Heart, Lung, and Blood Institute; Office of the President, University of California; Medical Center, University of Rochester; Glenmark Pharmaceuticals; Novartis Pharma; U.S. Food and Drug Administration; National Institutes of Health; Astellas Pharma; McGill University; Baxter Healthcare Corporation; University of Cambridge; Boston Scientific Corporation; EVER Neuro Pharma; Pfizer; Biogen; University of Rochester; Medicines Company; AcelRx Pharmaceuticals; Teva Pharmaceutical Industries; Celgene; GlaxoSmithKline; Johns Hopkins University; Université de Montréal; AstraZeneca; Eli Lilly and Company; Abbott Laboratories","keywords":"Medicine; Sedation; Mechanical ventilation; Critically ill; Intensive care medicine; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4507795,0.004296098,0.008325603,0.009560893,0.004706759,0.01147541,0.01169018,0.03083938,0.00656471],"category_scores_gemma":[0.6204186,0.005654482,0.02114144,0.009889931,0.005679249,0.008086425,0.008209165,0.02499679,0.009647889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01038519,"about_ca_system_score_gemma":0.09148173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009033903,"about_ca_topic_score_gemma":0.01087209,"domain_scores_codex":[0.4029608,0.4208339,0.1175617,0.006627338,0.04453801,0.007478252],"domain_scores_gemma":[0.2437734,0.4404326,0.07677527,0.0260518,0.197465,0.01550183],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005948808,0.0008180281,0.00499511,0.1679968,0.004601914,0.0006492973,0.003517299,0.002692032,0.002561301,0.01043159,0.4861318,0.309656],"study_design_scores_gemma":[0.02582736,0.002395217,0.01506724,0.4182425,0.01171259,0.0005668147,0.002271722,0.005226271,0.003656894,0.02532278,0.4888316,0.0008790644],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.005218471,0.054788,0.1059341,0.3629149,0.03640771,0.3819345,0.01241212,0.002442397,0.03794777],"genre_scores_gemma":[0.01452642,0.03340455,0.5736524,0.1029867,0.00619134,0.2561709,0.005167361,0.0004753271,0.007424944],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5492205,"threshold_uncertainty_score":0.6772867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.302334292715449,"score_gpt":0.5539748574166199,"score_spread":0.2516405647011709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}