{"id":"W3158685742","doi":"10.1097/ccm.0000000000005049","title":"Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III","year":2021,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Intensive Care Unit Cognitive Disorders","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Daiichi Sankyo Europe; National Heart, Lung, and Blood Institute; Office of the President, University of California; Medical Center, University of Rochester; Glenmark Pharmaceuticals; Novartis Pharma; U.S. Food and Drug Administration; National Institutes of Health; Astellas Pharma; McGill University; Baxter Healthcare Corporation; University of Cambridge; Boston Scientific Corporation; EVER Neuro Pharma; Pfizer; Biogen; University of Rochester; Medicines Company; AcelRx Pharmaceuticals; Teva Pharmaceutical Industries; Celgene; GlaxoSmithKline; Johns Hopkins University; Université de Montréal; AstraZeneca; Eli Lilly and Company; Abbott Laboratories","keywords":"Medicine; Sedation; Mechanical ventilation; Critically ill; Intensive care medicine; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004455984,0.0002118823,0.0009090324,0.0003669565,0.000155816,0.00003028096,0.00004475921,0.0002269238,0.0003269441],"category_scores_gemma":[0.3897066,0.0001889995,0.00008493481,0.0003346629,0.0004117829,0.000155259,0.0000376824,0.0002923442,0.000001969704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240254,"about_ca_system_score_gemma":0.001522907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004704653,"about_ca_topic_score_gemma":0.0001383189,"domain_scores_codex":[0.9946575,0.002405628,0.001585368,0.0006961245,0.0003723894,0.0002829502],"domain_scores_gemma":[0.9397491,0.03212111,0.0002410796,0.0002727335,0.02733627,0.000279741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"qualitative","study_design_scores_codex":[0.01030816,0.001774886,0.005723462,0.001739988,0.0002340004,0.00001690746,0.008008966,0.000003485578,0.01343025,0.009102592,0.005976117,0.9436812],"study_design_scores_gemma":[0.07691615,0.03423375,0.04333616,0.02926167,0.003678502,0.0001482199,0.6894584,0.02518352,0.03565271,0.05837289,0.002516286,0.001241785],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4678577,0.003105617,0.2394371,0.272565,0.003714025,0.01007714,0.0004502701,0.0001195394,0.002673507],"genre_scores_gemma":[0.9705646,0.0005194495,0.01807548,0.006834167,0.0004666146,0.0002969053,0.003154487,0.00003266301,0.00005562299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9424394,"threshold_uncertainty_score":0.7707178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.302334292715449,"score_gpt":0.5539748574166199,"score_spread":0.2516405647011709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}