{"id":"W3158750369","doi":"10.1136/gutjnl-2021-324789","title":"Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; St. Thomas Hospital","funders":"NIHR Cambridge Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; Medical Research Council; Genentech; Sheffield Teaching Hospitals NHS Foundation Trust; University College London Hospitals NHS Foundation Trust; Hospital for Sick Children; IC Design Education Center; Vifor Pharma; Crohn's and Colitis UK; University College London; Dr. Falk Pharma; National Institute for Health and Care Research; Royal Devon and Exeter NHS Foundation Trust; Galápagos; Roche; Royal Free London NHS Foundation Trust; University Hospitals Plymouth NHS Trust; University Hospitals Birmingham NHS Foundation Trust; University Hospitals of Leicester NHS Trust; Grifols; F. Hoffmann-La Roche; University Hospital Southampton NHS Foundation Trust; Celgene; St George's University Hospitals NHS Foundation Trust; Pfizer; Biogen; Sanofi; Public Health Wales; Celltrion; Celltrion Healthcare; Middlesex University; Amgen; UK Research and Innovation; NIHR Newcastle Biomedical Research Centre; Public Health England; University Hospitals Bristol NHS Foundation Trust; AstraZeneca; Eli Lilly and Company; Samsung; Bristol-Myers Squibb","keywords":"Medicine; Infliximab; Immunogenicity; Seroconversion; Vedolizumab; Vaccination; Antibody; Inflammatory bowel disease; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Internal medicine; Gastroenterology; Coronavirus disease 2019 (COVID-19); Disease; Tumor necrosis factor alpha; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496844,0.0002799908,0.0005508742,0.0002490934,0.0000921361,0.00006108704,0.0001473868,0.0001549267,0.00001448386],"category_scores_gemma":[0.0004726165,0.0002151731,0.00005240195,0.001260491,0.00007883923,0.0001335134,0.0001648729,0.0003566473,0.00005800999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523886,"about_ca_system_score_gemma":0.0004328842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189358,"about_ca_topic_score_gemma":0.001666982,"domain_scores_codex":[0.9977962,0.00009598348,0.0003283185,0.0005718794,0.0006464822,0.0005611351],"domain_scores_gemma":[0.9986474,0.0001030568,0.00009013809,0.0005007681,0.0005865145,0.00007213089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002156171,0.0005392469,0.9519227,0.00006100823,0.0002523826,0.0002989526,0.001030567,5.80133e-7,0.04143929,0.000007267968,0.001082576,0.001209268],"study_design_scores_gemma":[0.0139966,0.001144647,0.8690813,0.0003713712,0.00009011172,0.00003111099,0.000184543,0.00009918793,0.1068501,0.00002658828,0.007751645,0.0003728516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997124,0.0002571579,0.00001895731,0.001143834,0.00004417843,0.0006814289,0.00003695616,0.0000717146,0.0006217783],"genre_scores_gemma":[0.9625087,0.000004704614,0.0001214389,0.03706615,0.00003790401,0.00005222973,0.00004211824,0.0000488778,0.0001179162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0828414,"threshold_uncertainty_score":0.8774506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0267311298417141,"score_gpt":0.3092785522202133,"score_spread":0.2825474223784992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}