{"id":"W3158750369","doi":"10.1136/gutjnl-2021-324789","title":"Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; St. Thomas Hospital","funders":"NIHR Cambridge Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; Medical Research Council; Genentech; Sheffield Teaching Hospitals NHS Foundation Trust; University College London Hospitals NHS Foundation Trust; Hospital for Sick Children; IC Design Education Center; Vifor Pharma; Crohn's and Colitis UK; University College London; Dr. Falk Pharma; National Institute for Health and Care Research; Royal Devon and Exeter NHS Foundation Trust; Galápagos; Roche; Royal Free London NHS Foundation Trust; University Hospitals Plymouth NHS Trust; University Hospitals Birmingham NHS Foundation Trust; University Hospitals of Leicester NHS Trust; Grifols; F. Hoffmann-La Roche; University Hospital Southampton NHS Foundation Trust; Celgene; St George's University Hospitals NHS Foundation Trust; Pfizer; Biogen; Sanofi; Public Health Wales; Celltrion; Celltrion Healthcare; Middlesex University; Amgen; UK Research and Innovation; NIHR Newcastle Biomedical Research Centre; Public Health England; University Hospitals Bristol NHS Foundation Trust; AstraZeneca; Eli Lilly and Company; Samsung; Bristol-Myers Squibb","keywords":"Medicine; Infliximab; Immunogenicity; Seroconversion; Vedolizumab; Vaccination; Antibody; Inflammatory bowel disease; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Internal medicine; Gastroenterology; Coronavirus disease 2019 (COVID-19); Disease; Tumor necrosis factor alpha; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000493114,0.0002183384,0.0004336456,0.0001851315,0.0002117785,0.0004755143,0.000120928,0.0004514879,0.001182992],"category_scores_gemma":[0.001907754,0.0001673067,0.0003795121,0.000231707,0.0001872871,0.0002730799,0.000176868,0.000548202,0.0002238987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244891,"about_ca_system_score_gemma":0.000163823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004422592,"about_ca_topic_score_gemma":0.0005099168,"domain_scores_codex":[0.9995301,0.0001394149,0.00005670155,0.00008995268,0.0001081606,0.00007562165],"domain_scores_gemma":[0.9987538,0.0002484413,0.0006919042,0.00005307751,0.00008394786,0.0001688369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005803838,0.0003028025,0.9719421,0.0000508052,0.0001701459,0.0005187273,0.0001433935,0.0001829388,0.008699804,0.00003278198,0.0002034293,0.01194913],"study_design_scores_gemma":[0.0001193468,0.001566265,0.9964276,0.000008599138,0.00005725582,0.0008265263,0.00005283589,0.0002303085,0.0003946822,0.00001302911,0.0003006733,0.000002930442],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992309,0.0003598981,0.00003954143,0.00004654291,0.000005938224,0.000004361606,0.00002357563,0.00000241132,0.0002868451],"genre_scores_gemma":[0.9996886,0.00006244833,0.00003840306,0.00003982623,0.00001282687,0.000002599246,0.00006127979,7.587327e-7,0.00009325526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182992,"threshold_uncertainty_score":0.00395757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0267311298417141,"score_gpt":0.3092785522202133,"score_spread":0.2825474223784992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}