{"id":"W3158819655","doi":"10.1038/s41598-021-88829-w","title":"Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Dalhousie University; Canadian Cancer Society; Lotte and John Hecht Memorial Foundation; Dalhousie Medical Research Foundation","keywords":"Medicine; Blockade; Ranitidine; Immune system; Leukopenia; Histamine; Immunology; Context (archaeology); Immunophenotyping; Internal medicine; Pharmacology; Gastroenterology; Receptor; Antigen; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005900788,0.0003438349,0.0005994898,0.0002182648,0.0004511431,0.0003169115,0.0001233395,0.000374232,0.001491701],"category_scores_gemma":[0.0004383668,0.0002169543,0.0001811343,0.0001403714,0.0003637064,0.0002254768,0.0002523729,0.0003333029,0.0003974623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518196,"about_ca_system_score_gemma":0.0002326216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007896165,"about_ca_topic_score_gemma":0.000828428,"domain_scores_codex":[0.9996473,0.0001238023,0.00002098508,0.000092191,0.00004439225,0.0000713363],"domain_scores_gemma":[0.9998302,0.00004184915,0.00002474361,0.00001374649,0.00001275596,0.00007659992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06518444,0.01336765,0.3595663,0.0005309064,0.0002619497,0.005135314,0.001675612,0.0003493903,0.4857131,0.0002986866,0.001485472,0.06643125],"study_design_scores_gemma":[0.001630162,0.09639531,0.8808491,0.00002329859,0.0001980463,0.002207764,0.00042616,0.0004079578,0.01552386,0.0001636968,0.002156153,0.00001854219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984229,0.0005633658,0.0001274841,0.00002254644,0.00001506417,0.00006969382,0.00004142036,0.000005775834,0.0007317347],"genre_scores_gemma":[0.9988379,0.0002297895,0.0001123942,0.0001403327,0.00004098452,0.00006588065,0.00008823627,0.00000293852,0.0004815881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491701,"threshold_uncertainty_score":0.00499022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009253793433384996,"score_gpt":0.2321842253814786,"score_spread":0.2229304319480936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}