{"id":"W3158835541","doi":"10.1126/sciadv.abf3873","title":"Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Manitoba Arts Council; Cancer Research UK; Wellcome Trust; Francis Crick Institute; Medical Research Council; Office of Environmental Management; University of Kentucky","keywords":"Neurotransmitter; Synaptic vesicle; Neurotransmitter systems; Neuroscience; Neurotransmitter Agents; Vesicle; Biology; Chemistry; Cell biology; Central nervous system; Dopamine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003140824,0.00007107593,0.0001056407,0.00002496942,0.00009106895,0.0000118423,0.0001622199,0.00002724076,0.00001937348],"category_scores_gemma":[0.0002516161,0.00006548345,0.00005007787,0.000275821,0.0002384077,0.0000168087,0.00003194342,0.00003345456,0.000003725331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009534508,"about_ca_system_score_gemma":0.0001406382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006427378,"about_ca_topic_score_gemma":0.00001819722,"domain_scores_codex":[0.9990764,0.00002392248,0.0001671917,0.000346218,0.0001860879,0.0002001567],"domain_scores_gemma":[0.9994419,0.00001081409,0.00005212214,0.0002239943,0.0001836188,0.00008751458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003123259,0.00003482289,0.005683693,0.00001934914,0.00000471649,0.000002772988,0.00003893298,0.0006098822,0.9904084,0.00006970506,0.00000176755,0.003094712],"study_design_scores_gemma":[0.0001869362,0.0001105843,0.002249557,0.000009205904,0.000007212132,0.000003204914,0.00007434028,0.0001113042,0.9916489,0.0004203392,0.005089778,0.00008861697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288846,0.00196657,0.06861323,0.0001480436,0.0001168381,0.0001158701,0.000006169401,0.000006884103,0.0001417954],"genre_scores_gemma":[0.9964701,0.00003032056,0.003229559,0.0001262416,0.00004406949,0.000008467305,0.00004523298,0.000004090744,0.00004195469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06758546,"threshold_uncertainty_score":0.2670338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005959677184280957,"score_gpt":0.2331498002350274,"score_spread":0.2271901230507465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}