{"id":"W3158866558","doi":"10.1002/em.22433","title":"Concentration‐ and time‐dependent induction of <scp>Cyp1a</scp> and <scp>DNA</scp> damage response by benzo(a)pyrene in <scp>LMH</scp> three‐dimensional spheroids","year":2021,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"Environment and Climate Change Canada","keywords":"Spheroid; Benzo(a)pyrene; Flow cytometry; In vitro; Molecular biology; Cell culture; DNA damage; Chemistry; Gene expression; Toxicity; Downregulation and upregulation; Biology; DNA; Cell biology; Carcinogen; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285363,0.0002766465,0.000342853,0.0002134247,0.0001560673,0.0002579147,0.0001109138,0.0002318824,0.00118066],"category_scores_gemma":[0.0001116632,0.0001988146,0.0003721508,0.0002716046,0.0001915995,0.0001732793,0.0001414785,0.0005318723,0.0004398281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000372618,"about_ca_system_score_gemma":0.0002315261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620461,"about_ca_topic_score_gemma":0.002758117,"domain_scores_codex":[0.9998305,0.00002207499,0.00002354689,0.00005396787,0.00004656494,0.0000232667],"domain_scores_gemma":[0.9998023,0.0000417627,0.00004525307,0.00003610175,0.00004318177,0.00003146431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003114646,0.000009377924,0.000152175,0.00001691505,0.000003043225,0.0000179661,0.0000132923,0.00004030513,0.9993176,0.000007438456,0.00002678852,0.0003639028],"study_design_scores_gemma":[0.000003364497,0.0001672954,0.005315667,0.0000016759,0.000007696117,0.00005113664,0.00001947975,0.0002992563,0.9934639,0.000008030324,0.0006592544,0.000003264508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902638,0.0009554789,0.004930414,0.00009192471,0.00003317005,0.0001050563,0.001920922,0.0001474435,0.001551753],"genre_scores_gemma":[0.9830477,0.0009058776,0.006931699,0.00006552369,0.00001184348,0.0001921515,0.003337572,0.00004151329,0.005466249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620461,"threshold_uncertainty_score":0.003949642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00422749525237973,"score_gpt":0.1981189524543146,"score_spread":0.1938914572019348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}