{"id":"W3158866558","doi":"10.1002/em.22433","title":"Concentration‐ and time‐dependent induction of <scp>Cyp1a</scp> and <scp>DNA</scp> damage response by benzo(a)pyrene in <scp>LMH</scp> three‐dimensional spheroids","year":2021,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"Environment and Climate Change Canada","keywords":"Spheroid; Benzo(a)pyrene; Flow cytometry; In vitro; Molecular biology; Cell culture; DNA damage; Chemistry; Gene expression; Toxicity; Downregulation and upregulation; Biology; DNA; Cell biology; Carcinogen; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003544159,0.0003794454,0.0003672274,0.00005399943,0.0001634237,0.00005913435,0.0001124626,0.0003093067,0.00002179035],"category_scores_gemma":[0.0001199985,0.000413986,0.0001054572,0.0001075559,0.000314,0.00002451716,0.0004124419,0.0001539772,0.000006539505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005594806,"about_ca_system_score_gemma":0.00007362855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004490421,"about_ca_topic_score_gemma":0.00003985135,"domain_scores_codex":[0.9976756,0.0002708219,0.0004127082,0.0008445331,0.0003809431,0.0004153725],"domain_scores_gemma":[0.9990762,0.0001218244,0.0001656709,0.0003688382,0.0000243394,0.0002431545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002505059,0.0002629042,0.0114757,0.00002969044,0.000128355,0.00009615947,0.0001983941,0.0001389404,0.9860654,0.0000120553,0.0005883005,0.0009789873],"study_design_scores_gemma":[0.001422658,0.0004114115,0.08618359,0.00002224983,0.00008950866,0.0001177693,0.0009604789,0.0001704462,0.9066671,0.0000479159,0.003824276,0.00008263436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877687,0.01098827,0.0003383819,0.0000705811,0.00007181285,0.0003654479,0.0002626265,0.000009635804,0.0001245167],"genre_scores_gemma":[0.9957815,0.001396619,0.0005775707,0.0003391316,0.00004563012,0.00003592408,0.0006270282,0.00004801101,0.001148553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07939839,"threshold_uncertainty_score":0.9998312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00422749525237973,"score_gpt":0.1981189524543146,"score_spread":0.1938914572019348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}