{"id":"W3158888399","doi":"10.1097/cmr.0000000000000736","title":"Impact of the development of immune related adverse events in metastatic melanoma treated with PD -1 inhibitors","year":2021,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Metastatic melanoma; Adverse effect; Melanoma; Immune system; Medicine; Oncology; Cancer research; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001802912,0.0001528399,0.000420992,0.0003404563,0.0002655547,0.0006141979,0.0001435332,0.0002191855,0.0009730569],"category_scores_gemma":[0.005093875,0.00009142108,0.0009047898,0.0003485785,0.0002347837,0.0003555613,0.0002928081,0.0007128637,0.00006839429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003580418,"about_ca_system_score_gemma":0.0003370426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004821893,"about_ca_topic_score_gemma":0.001231135,"domain_scores_codex":[0.9986402,0.0005799762,0.0002031572,0.0001125885,0.0003137388,0.0001503288],"domain_scores_gemma":[0.9932112,0.002472642,0.003267742,0.0001545409,0.0004375195,0.0004563915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001941006,0.0001545288,0.9744077,0.00009583452,0.0004948143,0.0005001047,0.00004778325,0.0005767305,0.0008206892,0.00006120186,0.0002592183,0.02064036],"study_design_scores_gemma":[0.00003929853,0.001144998,0.9954538,0.00002830049,0.000233104,0.001388645,0.00005922504,0.0004426526,0.0003880197,0.00005323886,0.0007612512,0.000007445268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941394,0.003426608,0.0002460954,0.0001327447,0.00002872348,0.00001719691,0.0001623694,0.00000667691,0.001840203],"genre_scores_gemma":[0.9992711,0.0003499254,0.00006857383,0.00005418123,0.000027883,0.000005760061,0.00007932176,0.000002048158,0.0001411989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802912,"threshold_uncertainty_score":0.009534776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263292290255613,"score_gpt":0.3553960744760919,"score_spread":0.3127631515735357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}