{"id":"W3158898690","doi":"10.3389/fmicb.2021.682380","title":"USP18 Mediates Interferon Resistance of Dengue Virus Infection","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine; National Key Research and Development Program of China; Sichuan Province Science and Technology Support Program","keywords":"Interferon-stimulated gene; Biology; Dengue virus; Interferon; Virology; Transfection; STAT1; STAT2; ISG15; HeLa; Viral replication; Gene; Dengue fever; Virus; Cell culture; Innate immune system; Immunology; STAT protein; STAT3; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634343,0.0002906822,0.0002862798,0.0002699119,0.0001920097,0.000322585,0.0001204842,0.0002970859,0.001656107],"category_scores_gemma":[0.0001413303,0.0001423425,0.0004418957,0.0001280669,0.0001968351,0.0001937297,0.0002571437,0.0003765723,0.0004219506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985411,"about_ca_system_score_gemma":0.0001009411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002293575,"about_ca_topic_score_gemma":0.0001820699,"domain_scores_codex":[0.9998583,0.00002377373,0.00001620037,0.00003257315,0.00003547014,0.00003359761],"domain_scores_gemma":[0.9998922,0.00001449787,0.000038375,0.00001090017,0.00001652686,0.00002741837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001543018,0.00001706817,0.0007930351,0.00006323145,0.000007951013,0.0001232043,0.00002115919,0.00003589188,0.9966784,0.0001419467,0.0001058333,0.001858067],"study_design_scores_gemma":[0.00003333002,0.0002843419,0.0204216,0.00001462717,0.00003083757,0.001058816,0.00004952702,0.001280575,0.9681519,0.0001521075,0.008510563,0.00001171595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910302,0.004464652,0.002255522,0.0001275524,0.00004337706,0.00003827351,0.0006230295,0.00008133399,0.001336039],"genre_scores_gemma":[0.9941855,0.001525412,0.001344858,0.00006134187,0.00002502008,0.00002930301,0.0009243111,0.00001441388,0.001889973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656107,"threshold_uncertainty_score":0.005540252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005532891300501885,"score_gpt":0.2355518215037943,"score_spread":0.2300189302032924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}