{"id":"W3158927534","doi":"10.1161/circulationaha.120.053033","title":"Evidence-Based Assessment of Genes in Dilated Cardiomyopathy","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":512,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; Università degli Studi di Padova; Universiteit van Amsterdam; University of New South Wales; Imperial College London; Invitae; Victor Chang Cardiac Research Institute; Inselspital, Universitätsspital Bern; University College London; British Heart Foundation; National Human Genome Research Institute; Wellcome Trust; University of North Carolina at Chapel Hill; University of Bern; University of Ottawa; University of California, Los Angeles; University of South Carolina; Università degli Studi di Firenze; Johns Hopkins University; National Institute for Health and Care Research; Ohio State University","keywords":"LMNA; Dilated cardiomyopathy; Hypertrophic cardiomyopathy; MYH7; Medicine; Genetics; Cardiomyopathy; Genetic testing; Gene; Cardiology; Internal medicine; Biology; Heart failure; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004483715,0.0000756442,0.0003262071,0.0001317609,0.00001297936,0.000007888601,0.00002679826,0.00006800982,0.00004109565],"category_scores_gemma":[0.0002590063,0.00007928404,0.0002363527,0.0004247003,0.00002017989,0.00008650548,0.00001559278,0.00007620813,0.000003946608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001540153,"about_ca_system_score_gemma":0.0002915484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004398076,"about_ca_topic_score_gemma":0.000006074313,"domain_scores_codex":[0.9990152,0.0001268429,0.0002177907,0.0002001558,0.0003391845,0.000100786],"domain_scores_gemma":[0.9991924,0.00009667997,0.00005224385,0.0003881331,0.0002279058,0.00004259224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002764419,0.00006661455,0.790439,0.0002304169,0.00005396122,0.0001665334,0.00002409703,0.01724089,0.1738341,0.00003385864,0.000008001039,0.01787492],"study_design_scores_gemma":[0.001060258,0.00001973201,0.9553177,0.0007631408,0.0001587173,0.00002609065,0.00001478775,0.01879494,0.02371627,0.00002091922,0.00003972333,0.00006769845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883247,0.005360776,0.005174953,0.0001638578,0.0001171085,0.000319145,0.000001281643,0.00002445664,0.000513699],"genre_scores_gemma":[0.9986141,0.0001059136,0.001092534,0.0000454406,0.00005580406,0.00001822433,0.00004982319,0.00001239834,0.000005732626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1648787,"threshold_uncertainty_score":0.3233109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03915125726908125,"score_gpt":0.3138610433392005,"score_spread":0.2747097860701192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}