{"id":"W3158940958","doi":"10.1136/jitc-2020-002189","title":"Expanded antigen-experienced CD160+CD8+effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"CD8; Chronic lymphocytic leukemia; Immunology; T cell; Cytokine; Receptor; Cytotoxic T cell; Proinflammatory cytokine; Leukemia; Medicine; Antigen; Chemistry; Biology; Immune system; Internal medicine; Inflammation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005652388,0.0004187668,0.0006960189,0.000187179,0.0002839359,0.0001019853,0.0003519517,0.0003067483,0.0006509676],"category_scores_gemma":[0.00008933384,0.0003864582,0.0007348238,0.0003611438,0.0001516825,0.000029808,0.00005952375,0.0003029283,0.0000136266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001457333,"about_ca_system_score_gemma":0.003245159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003194041,"about_ca_topic_score_gemma":0.0000641103,"domain_scores_codex":[0.9973905,0.0002410197,0.0008004358,0.0005427276,0.0003570954,0.0006682227],"domain_scores_gemma":[0.9984974,0.0001051894,0.0003479577,0.0005382769,0.0003408352,0.0001703136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001352678,0.00006622489,0.0004762874,0.00008501035,0.0003728837,0.00001180894,0.0006137018,0.05451469,0.9300611,0.00000233695,0.002668824,0.009774456],"study_design_scores_gemma":[0.008891618,0.0008310213,0.0009601098,0.0002623297,0.00007700818,0.00008362418,0.0003644074,0.008438029,0.9023086,0.00001836131,0.07726394,0.0005009267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590784,0.03776089,0.001567053,0.00006423341,0.0008594244,0.0004726061,0.0001415417,0.00002263747,0.00003322428],"genre_scores_gemma":[0.9882643,0.007720628,0.0003627789,0.0003368443,0.001276639,0.0001960041,0.00008569634,0.0001084788,0.001648663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07459512,"threshold_uncertainty_score":0.9998587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071420997322421,"score_gpt":0.2843837342926516,"score_spread":0.2736695243194274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}