{"id":"W3158951931","doi":"","title":"Elamipretide (MTP-131) Topical Ophthalmic Solution for the Treatment of Leber's Hereditary Optic Neuropathy","year":2019,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Leber's hereditary optic neuropathy; Ophthalmology; Optic neuropathy; Dermatology; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007750758,0.0001867555,0.0002653429,0.000195791,0.0001833094,0.0001026445,0.0001970054,0.0002746643,0.0009764248],"category_scores_gemma":[0.0000824922,0.00005914235,0.0001421876,0.0001734487,0.0001395392,0.0001213947,0.0001020914,0.0004472287,0.0001447068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177411,"about_ca_system_score_gemma":0.0002284731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164888,"about_ca_topic_score_gemma":0.002197671,"domain_scores_codex":[0.9999683,0.000005744959,0.000003852135,0.000005537919,0.000007269433,0.000009349452],"domain_scores_gemma":[0.9999831,0.000004545918,0.000004106738,0.00000134601,0.000001550552,0.00000547356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01667592,0.001298323,0.002324929,0.000923194,0.0002022718,0.01776261,0.0001739427,0.0007452509,0.636064,0.001599649,0.005587346,0.3166426],"study_design_scores_gemma":[0.01012063,0.03211889,0.08539341,0.0003367163,0.001640119,0.07018125,0.0003618714,0.006575572,0.6893265,0.001132914,0.1026616,0.0001504976],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458715,0.04160635,0.002513749,0.00145752,0.0003551406,0.00008714871,0.0001999381,0.0001695932,0.007738929],"genre_scores_gemma":[0.9878389,0.008219207,0.001022579,0.0002331299,0.00008338229,0.00002109964,0.00009495133,0.00001155731,0.002475241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164888,"threshold_uncertainty_score":0.003266454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091218354909514,"score_gpt":0.3126614988074344,"score_spread":0.2817493152583393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}