{"id":"W3158957971","doi":"10.1371/journal.pone.0250454","title":"Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Universidad Nacional de Cuyo; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Epididymis; Downregulation and upregulation; Secretion; Biology; Castration; Western blot; Cathepsin D; Internal medicine; Endocrinology; Cathepsin; Immunocytochemistry; Androgen; Immunohistochemistry; Andrology; Sperm; Cell biology; Enzyme; Hormone; Immunology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009028943,0.0006549958,0.0004108022,0.0005898395,0.0001970134,0.0003303734,0.0001677826,0.0002836404,0.001637921],"category_scores_gemma":[0.00008659926,0.0002904205,0.0005474772,0.0002325788,0.0004050134,0.0002305735,0.0002468226,0.0007929531,0.0003471455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336344,"about_ca_system_score_gemma":0.0004382661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592524,"about_ca_topic_score_gemma":0.004540354,"domain_scores_codex":[0.9998316,0.0000106025,0.00001655167,0.00004019517,0.00005058883,0.00005053078],"domain_scores_gemma":[0.9997129,0.00001264685,0.00006696933,0.00002376297,0.0000192165,0.0001645036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003246702,0.00003098289,0.0004005803,0.0000399511,0.000005877908,0.0001153365,0.00001916237,0.00001680502,0.9984306,0.00002387806,0.00001978308,0.0005724519],"study_design_scores_gemma":[0.0000521825,0.002013676,0.05857445,0.00001203922,0.00004670522,0.000626896,0.0001691955,0.0002829948,0.9360276,0.00004586839,0.00212781,0.00002057774],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966041,0.001611506,0.0006009574,0.00005041967,0.00003813091,0.0000170999,0.0004378806,0.00008247863,0.0005574462],"genre_scores_gemma":[0.9903274,0.002022445,0.0008731801,0.00006732924,0.00002793176,0.00004037476,0.001050366,0.000028523,0.005562468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002592524,"threshold_uncertainty_score":0.005479455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839608168161265,"score_gpt":0.2257115294479451,"score_spread":0.2073154477663324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}