{"id":"W3158959319","doi":"10.1182/blood.v130.suppl_1.293.293","title":"The Identification of the Amino Acids on Platelet Factor 4 That Bind Pathogenic Antibodies in Heparin-Induced Thrombocytopenia","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; McMaster University","funders":"","keywords":"Platelet factor 4; Heparin; Alanine; Alanine scanning; Amino acid; Chemistry; Antibody; Heparin-induced thrombocytopenia; Molecular biology; Biochemistry; Mutant; Biology; Mutagenesis; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846368,0.0005026062,0.0002938921,0.0003786175,0.0001661438,0.0001906793,0.0002765966,0.0004741403,0.001108764],"category_scores_gemma":[0.0004824711,0.0001543331,0.0003064402,0.0002611706,0.0001719186,0.000125871,0.000189733,0.000308749,0.0003165181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276336,"about_ca_system_score_gemma":0.0002001474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008622141,"about_ca_topic_score_gemma":0.0006850874,"domain_scores_codex":[0.9997842,0.00005683162,0.00002980439,0.00003370561,0.0000572448,0.00003827466],"domain_scores_gemma":[0.9997751,0.00006746711,0.00006307558,0.00001163578,0.00004674331,0.00003606904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001059087,0.0002365462,0.02966814,0.0001353235,0.00006923072,0.001790111,0.00006137528,0.0006008812,0.9579579,0.0001139077,0.0002347425,0.008072785],"study_design_scores_gemma":[0.000162769,0.00210306,0.1367554,0.00005152846,0.0003168093,0.01998325,0.0001733722,0.004734659,0.8317317,0.0001383523,0.003822721,0.00002642293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983758,0.0004758525,0.0006317903,0.00005206376,0.00001209529,0.00001420561,0.0001134914,0.00001247701,0.0003121738],"genre_scores_gemma":[0.9983126,0.0001674474,0.001018253,0.00004996041,0.000006044579,0.000008004544,0.0002248498,0.000004907482,0.0002078508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108764,"threshold_uncertainty_score":0.003709197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05739589062322333,"score_gpt":0.3118316449550553,"score_spread":0.254435754331832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}