{"id":"W3158986043","doi":"10.1001/jamapsychiatry.2021.0638","title":"Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis","year":2021,"lang":"en","type":"review","venue":"JAMA Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Douglas College; McGill University","funders":"Janssen Pharmaceuticals; National Center for Advancing Translational Sciences; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; National Institute of Mental Health; Helse Sør-Øst RHF; National Health and Medical Research Council; Canadian Institutes of Health Research; NIHR Maudsley Biomedical Research Centre; Xiangya Hospital, Central South University; Department of Psychiatry, Columbia University; NIH Clinical Center; University of California, Irvine; University of California, San Francisco; National Institutes of Health; Novo Nordisk Fonden; Universitätsspital Zürich; Medical Research Council; Zhejiang University; University of Tokyo; Seoul National University Hospital; Meiji Seika Pharma; Karolinska Institutet; Department of Health and Aged Care, Australian Government; Instituto de Salud Carlos III; National Natural Science Foundation of China; National Research Foundation of Korea; Lundbeckfonden; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Ministerio de Economía y Competitividad; Lee Kong Chian School of Medicine, Nanyang Technological University; Universitetet i Oslo; Universität zu Lübeck; Consejo Nacional de Ciencia y Tecnología; TrygFonden; Central South University; University of Toronto; Generalitat de Catalunya; Diakonhjemmet; Russian Foundation for Basic Research; Vrije Universiteit Amsterdam; Swinburne University of Technology; College of Medicine, Seoul National University; Universität Heidelberg; Nanyang Technological University; Japan Society for the Promotion of Science; Astellas Pharma; University of Edinburgh; European Commission; European Regional Development Fund; Universitat de Barcelona; University of Roehampton; King's College London; Universitetet i Stavanger; Universität Zürich; Sunovion; National Alliance for Research on Schizophrenia and Depression; South London and Maudsley NHS Foundation Trust; Faculty of Health and Medical Sciences, University of Western Australia; National University of Singapore; National Institute for Health and Care Research; National Research Foundation; Rush University; Seoul National University; National Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Veterans Affairs; University of Pittsburgh; Universiteit Maastricht; Norges Forskningsråd; Australian Government; H. Lundbeck A/S; Fundación Alicia Koplowitz; Georgia State University; University of Maryland, Baltimore County; Brain and Behavior Research Foundation; McGill University; Japan Agency for Medical Research and Development; Maryland Department of Health and Mental Hygiene; Region Hovedstaden; University of Bern; Medical Center, University of Pittsburgh; New York City Department of Health and Mental Hygiene; Sir Run Run Shaw Hospital; Sistema Nacional de Investigadores; Universität Basel; Wellcome Trust; Eisai; University of Southern California; National Science Foundation; Horizon 2020 Framework Programme; University of Minnesota; Brigham and Women's Hospital","keywords":"Psychosis; Magnetic resonance imaging; Psychiatry; Psychology; Medicine; Association (psychology); Functional magnetic resonance imaging; Neuroscience; Psychotherapist; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004624476,0.0006217992,0.0009494753,0.001790721,0.0003991077,0.000954784,0.0007576788,0.0007442101,0.001047024],"category_scores_gemma":[0.01015742,0.0004310287,0.002850263,0.001815854,0.0004180611,0.0004659604,0.0006983764,0.0004786359,0.0000777194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118734,"about_ca_system_score_gemma":0.0003391665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002801036,"about_ca_topic_score_gemma":0.006498904,"domain_scores_codex":[0.9973882,0.001261004,0.0003537076,0.0006213791,0.000277403,0.00009829987],"domain_scores_gemma":[0.9952204,0.002105576,0.00172587,0.0004917523,0.00032179,0.0001347247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002834595,0.00005836614,0.9347847,0.001311799,0.04700869,0.0001946661,0.0001477984,0.0003725052,0.001022832,0.0001036047,0.0003334809,0.01182705],"study_design_scores_gemma":[0.0002503934,0.0003729349,0.9669134,0.0003972335,0.02979236,0.0003910298,0.0001407719,0.0005510637,0.0002975676,0.0002593333,0.0006129378,0.00002097646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9415002,0.05413516,0.001754408,0.0003233992,0.00006815617,0.00007443093,0.001199572,0.00003601957,0.0009086293],"genre_scores_gemma":[0.996151,0.002415607,0.0006933066,0.00006142453,0.00004167181,0.00003650427,0.0005000315,0.000005581835,0.00009487296],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004624476,"threshold_uncertainty_score":0.02445686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04392097170514179,"score_gpt":0.385376630003511,"score_spread":0.3414556582983692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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