{"id":"W3159001465","doi":"10.31635/ccschem.021.202000685","title":"Dynamic and Temporal Transcriptomic Analysis Reveals Ferroptosis-Mediated Antileukemia Activity of S-Dimethylarsino-Glutathione: Insights into Novel Therapeutic Strategy","year":2021,"lang":"en","type":"article","venue":"CCS Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glutathione; Library science; Transcriptome; Chemistry; World Wide Web; Computer science; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834357,0.0002553466,0.000363444,0.000325003,0.0001208192,0.0004248024,0.000132385,0.0002980832,0.001120912],"category_scores_gemma":[0.0001345187,0.0001215381,0.0003339849,0.0002977517,0.0001586096,0.0003361901,0.0001770711,0.0004084668,0.0003685498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470964,"about_ca_system_score_gemma":0.0002771888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000283784,"about_ca_topic_score_gemma":0.0004876751,"domain_scores_codex":[0.999877,0.00001030007,0.000008448654,0.00004019737,0.00003670849,0.00002736103],"domain_scores_gemma":[0.9999299,0.000008594819,0.00002121786,0.000005524841,0.00002227208,0.00001244313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002837818,0.00002105886,0.0009790584,0.0001190413,0.00001221446,0.00005976337,0.00002469522,0.0001083201,0.9905815,0.0001613839,0.0002860569,0.007363138],"study_design_scores_gemma":[0.0000667076,0.001220843,0.05733847,0.00004593556,0.0001587896,0.0006501772,0.0003660251,0.004683231,0.9116841,0.000877322,0.02287314,0.00003519252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9470336,0.02264112,0.01933773,0.001149019,0.0002710238,0.0001614255,0.005243265,0.0004550111,0.003707715],"genre_scores_gemma":[0.969907,0.01258337,0.007741548,0.000376428,0.00007325948,0.0001167947,0.003370566,0.00004889329,0.005782089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120912,"threshold_uncertainty_score":0.003749847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008354786220793848,"score_gpt":0.2494141584820817,"score_spread":0.2410593722612878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}