{"id":"W3159029006","doi":"10.1002/ctm2.401","title":"Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Moncton Hospital; Mount Sinai Hospital; Sunnybrook Health Science Centre; Hôpital Maisonneuve-Rosemont; St Mary's Hospital Centre; Hôpital du Sacré-Cœur de Montréal; Hôtel-Dieu de Québec; Hôpital Charles-Le Moyne; McGill University; Dr. Georges-L.-Dumont University Hospital Centre; Jewish General Hospital","funders":"","keywords":"Colorectal cancer; Medicine; Transcriptome; Oncology; Lesion; Cancer; Internal medicine; Exact test; KRAS; Pathology; Gene; Biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070601,0.00008261417,0.0001650781,0.00001918492,0.000053756,0.000007063683,0.00001745305,0.00004671975,0.00008689972],"category_scores_gemma":[0.0000807923,0.00005940169,0.00002180404,0.00007960717,0.0001031725,0.000004023983,0.000004895509,0.00004291426,7.647949e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005898086,"about_ca_system_score_gemma":0.0001386584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004525899,"about_ca_topic_score_gemma":0.001047464,"domain_scores_codex":[0.9992529,0.0001419485,0.0002448524,0.0002016877,0.00007200757,0.00008657837],"domain_scores_gemma":[0.9996217,0.0001639558,0.00002416479,0.00004381599,0.00006259072,0.00008376948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002024055,0.0003318753,0.9250402,0.00001431553,0.0002235964,0.00003026114,0.00119352,0.0001691441,0.06677999,0.0005665065,0.00006951468,0.003557028],"study_design_scores_gemma":[0.003886133,0.001035345,0.9852393,0.0000773756,0.00009436457,0.00003007722,0.0001919369,0.00008533079,0.005899922,0.0003465762,0.002990293,0.00012337],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923279,0.0004722408,0.0003143736,0.006524561,0.00004760425,0.0001310469,0.00008057293,0.000003046306,0.00009861218],"genre_scores_gemma":[0.9982998,0.0002837133,0.0004347251,0.0003344383,0.00006877942,0.00004090899,0.0001816876,0.000005876715,0.0003500516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06088006,"threshold_uncertainty_score":0.2422331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174531645991419,"score_gpt":0.3522445894022599,"score_spread":0.3104992729423457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}