{"id":"W3159029006","doi":"10.1002/ctm2.401","title":"Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Moncton Hospital; Mount Sinai Hospital; Sunnybrook Health Science Centre; Hôpital Maisonneuve-Rosemont; St Mary's Hospital Centre; Hôpital du Sacré-Cœur de Montréal; Hôtel-Dieu de Québec; Hôpital Charles-Le Moyne; McGill University; Dr. Georges-L.-Dumont University Hospital Centre; Jewish General Hospital","funders":"","keywords":"Colorectal cancer; Medicine; Transcriptome; Oncology; Lesion; Cancer; Internal medicine; Exact test; KRAS; Pathology; Gene; Biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328608,0.0001516868,0.0002560379,0.0004095122,0.0001195205,0.0002763597,0.0001101085,0.0001994623,0.001667474],"category_scores_gemma":[0.0007685408,0.00008732254,0.0001609347,0.0004453763,0.0001510209,0.0001278747,0.0001861157,0.000218813,0.0002055212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370998,"about_ca_system_score_gemma":0.0001191338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007351317,"about_ca_topic_score_gemma":0.0009029687,"domain_scores_codex":[0.9998749,0.00001343365,0.000007489569,0.0000420974,0.00004000805,0.00002191838],"domain_scores_gemma":[0.9996246,0.00008832093,0.0001821518,0.00002301402,0.00004011485,0.00004161447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00204409,0.00005780952,0.3261821,0.0001992695,0.0001772697,0.0004536831,0.0001865479,0.001155612,0.6462744,0.0001026379,0.0003282421,0.02283824],"study_design_scores_gemma":[0.00001197788,0.000228149,0.9752431,0.00000706636,0.00006970385,0.0009683418,0.0000683906,0.001594939,0.02104954,0.000101662,0.0006482312,0.000008998984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983087,0.0003757103,0.000381244,0.00002537463,0.000002426332,0.000005426888,0.0006621381,0.00001869,0.0002203875],"genre_scores_gemma":[0.9986128,0.0001389359,0.0003542804,0.0000148916,0.000003144811,0.00001363856,0.0006337016,0.000008552912,0.0002201611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667474,"threshold_uncertainty_score":0.00557822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174531645991419,"score_gpt":0.3522445894022599,"score_spread":0.3104992729423457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}