{"id":"W3159046749","doi":"10.3389/fimmu.2021.655027","title":"Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Mitacs; BC Children's Hospital; Michael Smith Health Research BC; Child and Family Research Institute","keywords":"Biology; Immunology; STAT protein; Chronic mucocutaneous candidiasis; Cord blood; T cell; STAT3; Cytokine; Phenotype; Cell biology; Immune system; Signal transduction; Gene; Medicine; Internal medicine; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005671356,0.0005479501,0.0009747509,0.0005724758,0.0004337736,0.0000540253,0.001032553,0.0008884602,0.00166182],"category_scores_gemma":[0.0003882423,0.000579919,0.0002799681,0.0006327081,0.001608871,0.0004761743,0.0004428012,0.001214153,0.0003117854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539059,"about_ca_system_score_gemma":0.000540058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002536793,"about_ca_topic_score_gemma":0.00004690555,"domain_scores_codex":[0.9956757,0.001238319,0.0008600048,0.0009509635,0.00009563941,0.001179409],"domain_scores_gemma":[0.9979766,0.0001076793,0.0002977845,0.001359563,0.0002392145,0.00001914215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006014208,0.001813667,0.01047542,0.00007058353,0.001624083,0.0005987257,0.01184758,0.00008490467,0.7179645,0.003089145,0.01367277,0.2327444],"study_design_scores_gemma":[0.008989424,0.0007660361,0.2082907,0.0002391766,0.0001369513,0.0007407873,0.05524609,0.00003922956,0.1368659,0.003172045,0.5837339,0.001779744],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7755083,0.212814,0.0009138061,0.0003660379,0.00804419,0.0002365265,0.00006291209,0.0001975355,0.001856602],"genre_scores_gemma":[0.9856359,0.001050765,0.0006620781,0.0006142948,0.00001802103,0.00007576911,0.0005808286,0.00007687842,0.01128542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5810986,"threshold_uncertainty_score":0.9996652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008106657965875012,"score_gpt":0.2271800599233295,"score_spread":0.2190734019574544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}