{"id":"W3159073875","doi":"10.1038/s41591-021-01355-0","title":"Delayed production of neutralizing antibodies correlates with fatal COVID-19","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"National Institute for Occupational Safety and Health; National Institute on Aging; National Center for Advancing Translational Sciences; Yale School of Public Health, Yale University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Gruber Foundation; Yale University; National Science Foundation; U.S. Department of Health and Human Services; Pew Charitable Trusts; G. Harold and Leila Y. Mathers Foundation; U.S. Department of Veterans Affairs; Ludwig Family Foundation; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Coronavirus disease 2019 (COVID-19); Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; 2019-20 coronavirus outbreak; Neutralizing antibody; Betacoronavirus; Coronavirus Infections; Biology; Medicine; Immunology; Outbreak; Disease; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005502729,0.000449708,0.0004099433,0.0004446666,0.0002464069,0.0006413223,0.0003202909,0.0008069178,0.005009638],"category_scores_gemma":[0.001444411,0.0002876025,0.0003402934,0.0001750721,0.0002832334,0.0002903941,0.0003814397,0.00170161,0.001124864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004424447,"about_ca_system_score_gemma":0.000321069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006234305,"about_ca_topic_score_gemma":0.000360518,"domain_scores_codex":[0.9993806,0.00009790192,0.00003701553,0.00008638027,0.0001374401,0.0002606163],"domain_scores_gemma":[0.998515,0.0002668003,0.0005163174,0.0001609106,0.0002127004,0.0003282307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004434188,0.001199672,0.1025983,0.000144837,0.0001218433,0.001615549,0.00012768,0.0003061045,0.8719337,0.0007733594,0.002496319,0.01424847],"study_design_scores_gemma":[0.0002774656,0.007445819,0.7671944,0.00005652924,0.000133451,0.01102813,0.0003239542,0.002757635,0.200449,0.0006936981,0.00960314,0.00003664733],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918047,0.001278766,0.001238183,0.000214553,0.0001158911,0.00008697709,0.0005628056,0.00009490908,0.004603157],"genre_scores_gemma":[0.9967056,0.0002159466,0.0003331765,0.0001216921,0.00005320915,0.00003278195,0.0007877224,0.00001038574,0.00173948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005009638,"threshold_uncertainty_score":0.01675898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953531465965856,"score_gpt":0.3658259923639294,"score_spread":0.3362906777042708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}