{"id":"W3159099664","doi":"10.2337/dbi20-0034","title":"Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes","year":2021,"lang":"en","type":"review","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United Kingdom; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Prohormone; Type 2 diabetes; Medicine; Diabetes mellitus; Internal medicine; Bioinformatics; Endocrinology; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006166377,0.0008940988,0.001152758,0.002083272,0.0002313467,0.0008478792,0.0006909691,0.0008010295,0.002498838],"category_scores_gemma":[0.0007683203,0.000234122,0.0004094576,0.002394467,0.0004227828,0.001050878,0.0006801498,0.001698033,0.001895835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005171445,"about_ca_system_score_gemma":0.0008745006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017291,"about_ca_topic_score_gemma":0.001601372,"domain_scores_codex":[0.999827,0.00002680598,0.00002909673,0.00003098169,0.00006781709,0.00001831766],"domain_scores_gemma":[0.9996804,0.0001469187,0.00005377719,0.000009657262,0.00007987601,0.00002941435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001023536,0.00004494466,0.0002232807,0.01507767,0.00007522057,0.0001487661,0.00003689404,0.0002690833,0.000984538,0.001876228,0.02022585,0.9609351],"study_design_scores_gemma":[0.00002099477,0.0001089737,0.002029226,0.007124171,0.0001605127,0.00207939,0.000074581,0.0001024415,0.0004478777,0.002515827,0.9853109,0.00002511844],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006590632,0.9991308,0.00005569624,0.0001275464,0.000129501,0.000001910858,0.00001180724,0.000005487807,0.00047133],"genre_scores_gemma":[0.0003249627,0.9991936,0.00007918606,0.000095023,0.00008358548,0.000002381899,0.00001607269,7.905468e-7,0.0002044228],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002498838,"threshold_uncertainty_score":0.008359432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03550260470961827,"score_gpt":0.299834459335934,"score_spread":0.2643318546263157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}