{"id":"W3159099664","doi":"10.2337/dbi20-0034","title":"Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes","year":2021,"lang":"en","type":"review","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United Kingdom; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Prohormone; Type 2 diabetes; Medicine; Diabetes mellitus; Internal medicine; Bioinformatics; Endocrinology; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003015318,0.0004499508,0.002158961,0.0003519497,0.00005563568,0.00008362783,0.00007677014,0.0003664361,0.0001238659],"category_scores_gemma":[0.0003962782,0.0003646564,0.0001894611,0.0007274745,0.00008474455,0.0001064032,0.00007592096,0.0004430746,0.00004880484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008912,"about_ca_system_score_gemma":0.0003690809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002260961,"about_ca_topic_score_gemma":2.34651e-7,"domain_scores_codex":[0.9979586,0.0001415718,0.0005967447,0.0005851217,0.0002312074,0.0004867594],"domain_scores_gemma":[0.9988987,0.0002279708,0.0002410855,0.0003196865,0.0001241976,0.0001883046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004494237,0.0001771195,0.004544734,0.04775057,0.0001067198,0.0000106789,0.00005920974,8.849683e-8,0.0005133027,0.00001033916,0.0008224189,0.9460003],"study_design_scores_gemma":[0.001116063,0.0003437312,0.0004768987,0.05246801,0.001775464,0.000006176321,0.00005836627,0.0002759605,0.0008496332,0.0000413114,0.9418832,0.0007051692],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05459517,0.9425706,6.759582e-7,0.00003585261,0.0002205935,0.0007573778,0.00001259053,0.0000802292,0.001726962],"genre_scores_gemma":[0.001421409,0.9960404,0.0003022419,0.0001827165,0.000278729,0.0001804693,0.0007278729,0.00007970906,0.0007864593],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9452952,"threshold_uncertainty_score":0.9998806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03550260470961827,"score_gpt":0.299834459335934,"score_spread":0.2643318546263157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}