{"id":"W3159118045","doi":"10.1016/j.celrep.2021.109069","title":"mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"LGR5; PI3K/AKT/mTOR pathway; Biology; Cancer research; Carcinogenesis; Cell biology; RPTOR; Progenitor cell; Stem cell; Signal transduction; Cancer; Cancer stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003461531,0.0003304072,0.0003357341,0.00008634941,0.0001796429,0.00009255482,0.000118957,0.0002379524,0.00005815932],"category_scores_gemma":[0.0002021752,0.0003345721,0.0001262743,0.0002512577,0.000120408,0.00001028041,0.0002797864,0.0001372946,0.000003086255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000420579,"about_ca_system_score_gemma":0.0003032476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002050725,"about_ca_topic_score_gemma":0.000004399294,"domain_scores_codex":[0.9976984,0.00008763511,0.0005185977,0.0009465973,0.0002798358,0.0004689599],"domain_scores_gemma":[0.9985105,0.00003433245,0.0003172314,0.0006351113,0.0002398493,0.0002629188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004174584,0.00006588221,0.008568167,0.00009819838,0.00006661148,0.0007842977,0.00004786751,0.00003712493,0.9805295,8.771196e-7,0.000469493,0.009290216],"study_design_scores_gemma":[0.0003504571,0.0002131622,0.001872342,0.00003901346,0.0001125908,0.001834843,0.00007330537,0.00004411913,0.9881496,0.0001372887,0.006797473,0.0003757513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977428,0.02076336,0.0007622298,0.00003995031,0.0005303684,0.0002433337,0.00003018745,0.00003635956,0.0001661893],"genre_scores_gemma":[0.993682,0.00103166,0.003829191,0.00007476336,0.0007334676,0.00005123021,0.0001198425,0.00006718952,0.0004106965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0197317,"threshold_uncertainty_score":0.9999107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009308895105733654,"score_gpt":0.2131470544934852,"score_spread":0.2038381593877515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}