{"id":"W3159131528","doi":"10.1080/09546634.2021.1902925","title":"Efficacy, tolerability, patient usability, and satisfaction with a 2 mL pre-filled syringe containing secukinumab 300 mg in patients with moderate to severe plaque psoriasis: results from the phase 3 randomized, double-blind, placebo-controlled ALLURE study","year":2021,"lang":"en","type":"article","venue":"Journal of Dermatological Treatment","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; University of British Columbia","funders":"","keywords":"Secukinumab; Medicine; Tolerability; Placebo; Psoriasis Area and Severity Index; Psoriasis; Bioequivalence; Randomized controlled trial; Clinical endpoint; Adverse effect; Internal medicine; Pharmacokinetics; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001955064,0.0006956689,0.001594216,0.0002193632,0.000345774,0.0005084232,0.0004862353,0.0008118922,0.003334242],"category_scores_gemma":[0.001418855,0.0003876697,0.001339577,0.0002465575,0.0006200664,0.0006025643,0.0002424063,0.00147843,0.0003618109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168384,"about_ca_system_score_gemma":0.0004100513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000307585,"about_ca_topic_score_gemma":0.0007527902,"domain_scores_codex":[0.999103,0.0005304724,0.00006890079,0.00009284214,0.0001325518,0.00007221402],"domain_scores_gemma":[0.9987697,0.0004196828,0.0004523823,0.00008224011,0.00006876505,0.0002070531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7727521,0.06346393,0.01120201,0.0022136,0.002671864,0.0001152802,0.0003830713,0.0006969704,0.03447201,0.00009146793,0.001065916,0.1108718],"study_design_scores_gemma":[0.3747168,0.5746591,0.04401693,0.00005733091,0.001176442,0.0002019142,0.00009328036,0.0008776566,0.003433657,0.00006948853,0.0006592071,0.0000382961],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972472,0.001385603,0.0002381661,0.00009105688,0.00002545101,0.000491398,0.0001492637,0.0000292166,0.0003425898],"genre_scores_gemma":[0.9978564,0.0005901,0.0004883084,0.0001993229,0.0000596261,0.000371235,0.0001557364,0.000005159015,0.0002741253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003334242,"threshold_uncertainty_score":0.01115417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362595623354314,"score_gpt":0.2691566812626643,"score_spread":0.2455307250291212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}