{"id":"W3159190554","doi":"10.1002/bit.27799","title":"Combined local delivery of tacrolimus and stem cells in hydrogel for enhancing peripheral nerve regeneration","year":2021,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"Tacrolimus; Chemistry; PLGA; Stem cell; Pharmacology; Viability assay; Mesenchymal stem cell; Transplantation; Fibrin; Regeneration (biology); Self-healing hydrogels; Drug delivery; Adipose tissue; Biomedical engineering; Cell; In vitro; Medicine; Surgery; Pathology; Immunology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193754,0.0003392374,0.0002766188,0.0002294726,0.00009314015,0.0002682592,0.0001738099,0.0002085193,0.0007817373],"category_scores_gemma":[0.00007980251,0.0001036589,0.0002066351,0.0001359303,0.0001492767,0.0002691099,0.0001827538,0.0002402593,0.0001732796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229975,"about_ca_system_score_gemma":0.0002273445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005241288,"about_ca_topic_score_gemma":0.001427642,"domain_scores_codex":[0.9998964,0.00001170078,0.000009694242,0.00001988685,0.00004179891,0.00002053563],"domain_scores_gemma":[0.999954,0.000008804147,0.00001426851,0.000003814569,0.000005725794,0.0000133495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004167604,0.00002398854,0.00005033739,0.00006480973,0.000005773216,0.00003805522,0.000008226974,0.00013301,0.9967927,0.00004580829,0.0000191369,0.002776342],"study_design_scores_gemma":[0.00001465235,0.0003259745,0.000521808,0.000007229212,0.00002897092,0.0001062,0.000009019837,0.0009024669,0.9969995,0.00001308153,0.001067511,0.000003629748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857162,0.004522658,0.007899163,0.0000677622,0.00006609301,0.00006107098,0.0000927612,0.00007173952,0.001502625],"genre_scores_gemma":[0.988359,0.001852834,0.00790176,0.00003055052,0.00002585128,0.0000576443,0.00005828937,0.00001408991,0.001700063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007817373,"threshold_uncertainty_score":0.002615213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246389033389763,"score_gpt":0.2132218714036142,"score_spread":0.2007579810697166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}