{"id":"W3159190554","doi":"10.1002/bit.27799","title":"Combined local delivery of tacrolimus and stem cells in hydrogel for enhancing peripheral nerve regeneration","year":2021,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"Tacrolimus; Chemistry; PLGA; Stem cell; Pharmacology; Viability assay; Mesenchymal stem cell; Transplantation; Fibrin; Regeneration (biology); Self-healing hydrogels; Drug delivery; Adipose tissue; Biomedical engineering; Cell; In vitro; Medicine; Surgery; Pathology; Immunology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008042918,0.00009060626,0.0001417041,0.00009328772,0.00006007892,0.00001194062,0.00004420998,0.000214072,0.000001021719],"category_scores_gemma":[0.00001392086,0.00008816131,0.00002165126,0.0001670225,0.00009841818,0.00007401127,0.00004427251,0.00009918402,1.628248e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001642439,"about_ca_system_score_gemma":0.00001623474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006417314,"about_ca_topic_score_gemma":0.0000652599,"domain_scores_codex":[0.9993779,0.00001692766,0.0001817127,0.0002403869,0.00004031632,0.0001427723],"domain_scores_gemma":[0.999787,0.00004419399,0.0000374957,0.00009289153,0.00001714249,0.00002127972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002418427,0.00001901729,0.00004868773,0.00006095158,0.000003338438,0.00001325176,0.00003587854,0.001567429,0.9874045,0.00566422,0.000001842978,0.005156731],"study_design_scores_gemma":[0.0003928371,0.000123856,0.00003172686,0.00002847978,0.000005864908,0.0000267727,0.00006126917,0.06438433,0.9347111,0.00007904969,0.00006646197,0.00008823469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720927,0.000594659,0.02666471,0.000319426,0.0001521847,0.0001168233,0.00001204089,0.00004501762,0.000002445479],"genre_scores_gemma":[0.9988472,0.0002237442,0.0008097188,0.00003442973,0.00002200811,0.00001143149,0.000003096631,0.000007767278,0.0000406284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0628169,"threshold_uncertainty_score":0.3595114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246389033389763,"score_gpt":0.2132218714036142,"score_spread":0.2007579810697166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}