{"id":"W3159228500","doi":"10.1002/prca.202100003","title":"Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease","year":2021,"lang":"en","type":"article","venue":"PROTEOMICS - CLINICAL APPLICATIONS","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; School of Medicine, Duke University; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Instituto Tecnológico de Costa Rica; Georgia Clinical and Translational Science Alliance; Cedars-Sinai Medical Center; Johns Hopkins University","keywords":"Medicine; Proteome; Haptoglobin; Internal medicine; Neurogranin; Biomarker; Disease; Sickle cell anemia; Cell; Hemopexin; Gastroenterology; Bioinformatics; Biology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000658479,0.0002408733,0.0002700874,0.0004954578,0.0001913187,0.0003365632,0.0001485542,0.0002471886,0.0004606107],"category_scores_gemma":[0.0007458193,0.00009079148,0.0001707226,0.0004958308,0.0002478082,0.0001677081,0.0002699845,0.000239155,0.00007886405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549724,"about_ca_system_score_gemma":0.0002442202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003973504,"about_ca_topic_score_gemma":0.0006531068,"domain_scores_codex":[0.9997869,0.00006255825,0.00002107773,0.00004750574,0.00006331227,0.0000187062],"domain_scores_gemma":[0.9996859,0.00006855535,0.0001586692,0.00001303281,0.00003757655,0.00003637934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003366124,0.0001825059,0.6972225,0.0006767588,0.0003338634,0.001261659,0.0004066763,0.0005489439,0.2604314,0.0002038619,0.00113806,0.03422764],"study_design_scores_gemma":[0.00009347513,0.0008845276,0.9598927,0.0000431256,0.0001446139,0.003363268,0.0002289915,0.0008205163,0.03269001,0.0001743531,0.001656698,0.000007778025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970816,0.002090052,0.0003143762,0.00007690136,0.000005794706,0.00001222313,0.000232888,0.000009076957,0.0001770511],"genre_scores_gemma":[0.9969029,0.00101249,0.001481299,0.00007552235,0.00001291202,0.00001829203,0.0003791333,0.00000321498,0.0001142183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000658479,"threshold_uncertainty_score":0.003482401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638598089102757,"score_gpt":0.2885316714529232,"score_spread":0.2721456905618957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}