{"id":"W3159228500","doi":"10.1002/prca.202100003","title":"Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease","year":2021,"lang":"en","type":"article","venue":"PROTEOMICS - CLINICAL APPLICATIONS","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; School of Medicine, Duke University; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Instituto Tecnológico de Costa Rica; Georgia Clinical and Translational Science Alliance; Cedars-Sinai Medical Center; Johns Hopkins University","keywords":"Medicine; Proteome; Haptoglobin; Internal medicine; Neurogranin; Biomarker; Disease; Sickle cell anemia; Cell; Hemopexin; Gastroenterology; Bioinformatics; Biology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003648428,0.0003424269,0.0005747031,0.0001379273,0.0001180897,0.0000723987,0.0002663527,0.0002266482,0.00006004181],"category_scores_gemma":[0.0001913747,0.0002969456,0.0002273801,0.001081364,0.0002770447,0.0001648202,0.000150625,0.001097334,0.0001254264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009737291,"about_ca_system_score_gemma":0.001149695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007237257,"about_ca_topic_score_gemma":0.00002944005,"domain_scores_codex":[0.9968721,0.0001873992,0.001052222,0.001011987,0.0003178794,0.0005583973],"domain_scores_gemma":[0.9978943,0.0001284014,0.0002402119,0.0009728652,0.0001220312,0.0006421661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007485513,0.006567687,0.9832508,0.0002504852,0.00005473221,0.0001112065,0.00005705162,0.00053755,0.006455593,0.0004515528,0.0001460274,0.001368769],"study_design_scores_gemma":[0.007363984,0.000196711,0.9841554,0.0001819591,0.0002631798,0.00001100269,0.00005531534,0.00133711,0.00332673,0.001565721,0.001046035,0.0004968568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852919,0.0005496454,0.003183639,0.003814297,0.00003505036,0.006400603,0.0002176619,0.0001053526,0.0004018782],"genre_scores_gemma":[0.9902562,0.0005768116,0.004091868,0.0009281247,0.0001224979,0.002477759,0.0005081437,0.00008669789,0.0009518731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006615433,"threshold_uncertainty_score":0.9999483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638598089102757,"score_gpt":0.2885316714529232,"score_spread":0.2721456905618957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}