{"id":"W3159257193","doi":"10.1371/journal.pbio.3001237","title":"Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies","year":2021,"lang":"en","type":"article","venue":"PLoS Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genome British Columbia; Canada Excellence Research Chairs, Government of Canada; TRIUMF; Human Frontier Science Program","keywords":"Biology; Neutralization; Mutant; Cryo-electron microscopy; Infectivity; Mutation; Epitope; Neutralizing antibody; Protein structure; Antibody; Spike (software development); Spike Protein; Biophysics; Plasma protein binding; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Receptor; Cell biology; Coronavirus disease 2019 (COVID-19); Virus; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036014,0.0001591664,0.0004067263,0.0001015765,0.0000625912,0.00001377503,0.0001379472,0.0001217436,0.000004829624],"category_scores_gemma":[0.00009781236,0.00009588742,0.00004807481,0.0002613919,0.000400874,0.0000261883,0.00013976,0.0003066195,0.000001660246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004397969,"about_ca_system_score_gemma":0.0002118474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003602412,"about_ca_topic_score_gemma":0.0006678162,"domain_scores_codex":[0.9987749,0.0001575798,0.0002208316,0.0003344148,0.0001328502,0.0003794379],"domain_scores_gemma":[0.9994475,0.00005134693,0.00007291955,0.0003005201,0.0001129031,0.00001482541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002843569,0.0000832819,0.1912136,0.0001835547,0.00005175095,0.00003062683,0.000186242,8.164525e-8,0.8072177,0.0004907447,0.0000353123,0.0002227345],"study_design_scores_gemma":[0.00102846,0.0004207274,0.09149043,0.0001104926,0.00002735639,0.00007081844,0.0001045808,0.00002487833,0.9033803,0.0005712581,0.002677594,0.00009304813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968954,0.0009493331,0.000009089298,0.001265846,0.00002223934,0.0005261757,0.00001201925,0.00001740704,0.0003024706],"genre_scores_gemma":[0.9934989,0.00001754548,0.0006054264,0.00577871,0.00004232872,0.00002208342,0.00000789641,0.00001651291,0.00001061329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0997232,"threshold_uncertainty_score":0.3910175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05611211366693601,"score_gpt":0.3645937145879224,"score_spread":0.3084816009209864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}