{"id":"W3159278371","doi":"10.1096/fj.202002645r","title":"Hsp90 and its co‐chaperone Sti1 control TDP‐43 misfolding and toxicity","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"Hsp90; Toxicity; Chaperone (clinical); Protein folding; Amyotrophic lateral sclerosis; Inclusion bodies; Cell biology; Protein aggregation; Co-chaperone; Heat shock protein; Biology; Chemistry; Biochemistry; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476804,0.0002663486,0.000244217,0.0001908987,0.0001293925,0.0004037977,0.0001690345,0.0002191025,0.0006309713],"category_scores_gemma":[0.000145207,0.0001241614,0.0001569725,0.0001178392,0.0002178593,0.0002419503,0.0002514904,0.0004198948,0.000271251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512711,"about_ca_system_score_gemma":0.0001471443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003932658,"about_ca_topic_score_gemma":0.0005582399,"domain_scores_codex":[0.9998789,0.00002325922,0.0000110106,0.00001986319,0.00002878868,0.0000382001],"domain_scores_gemma":[0.9998953,0.000007767102,0.00004032659,0.000009386783,0.00001168545,0.00003553078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516755,0.00002658473,0.0007569683,0.00004409739,0.000007439668,0.00007358946,0.00002328132,0.0002302299,0.9947146,0.0001564966,0.0001221257,0.003692858],"study_design_scores_gemma":[0.00002495249,0.0004517771,0.04807428,0.00001433657,0.00004451152,0.000760283,0.0001147592,0.004178078,0.9429582,0.0003583999,0.003010148,0.00001029434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915338,0.005512086,0.001318089,0.0001645486,0.00001867049,0.000009594792,0.0001386995,0.00009588933,0.00120864],"genre_scores_gemma":[0.9979581,0.000908472,0.0002792561,0.00002674098,0.00000670553,0.000006900088,0.00005619946,0.000006969829,0.000750707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006309713,"threshold_uncertainty_score":0.002548635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03720295661651143,"score_gpt":0.3041578951152378,"score_spread":0.2669549384987264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}