{"id":"W3159278371","doi":"10.1096/fj.202002645r","title":"Hsp90 and its co‐chaperone Sti1 control TDP‐43 misfolding and toxicity","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"Hsp90; Toxicity; Chaperone (clinical); Protein folding; Amyotrophic lateral sclerosis; Inclusion bodies; Cell biology; Protein aggregation; Co-chaperone; Heat shock protein; Biology; Chemistry; Biochemistry; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006672823,0.000121864,0.0002695705,0.00004512417,0.0003413081,0.0001164554,0.00008473446,0.00006654658,0.0007470042],"category_scores_gemma":[0.0002768022,0.00007389841,0.00005322923,0.00009781555,0.0001113123,0.0001103203,0.00007131748,0.0006051216,0.00002125795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006434158,"about_ca_system_score_gemma":0.0001156963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008372176,"about_ca_topic_score_gemma":0.000003474493,"domain_scores_codex":[0.998656,0.0001940878,0.0002205744,0.0001664034,0.0004207083,0.0003422513],"domain_scores_gemma":[0.999097,0.0001773858,0.00006722548,0.0001444471,0.0001575224,0.0003564406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002133253,0.00004200533,0.007612716,0.00002649587,0.0001161171,0.0003876236,0.000280639,0.000005753805,0.9873934,0.00007897837,0.0004598853,0.003383111],"study_design_scores_gemma":[0.01687993,0.001108379,0.4364438,0.00077892,0.0004224117,0.01808875,0.0008414197,0.006598015,0.5154141,0.0007332671,0.00221013,0.000480901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846305,0.004489234,0.0001629397,0.009958152,0.00006765279,0.0001579034,0.00001004979,0.00001380816,0.0005097302],"genre_scores_gemma":[0.9956885,0.001641741,0.0001020639,0.001208291,0.0004039368,0.000002790654,0.000001779426,0.00001636637,0.0009345357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4719793,"threshold_uncertainty_score":0.8179173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03720295661651143,"score_gpt":0.3041578951152378,"score_spread":0.2669549384987264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}