{"id":"W3159357214","doi":"10.3390/microorganisms9050926","title":"Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba; Sunnybrook Health Science Centre; Université Laval","funders":"","keywords":"In silico; Nonsynonymous substitution; Mutation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Chemistry; Gene; Genetics; Coronavirus disease 2019 (COVID-19); Medicine; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039434,0.001062324,0.001038558,0.0006130137,0.000561438,0.0007564574,0.0007248272,0.0007883966,0.00227527],"category_scores_gemma":[0.000864119,0.0003384148,0.001220153,0.0004303037,0.0002096899,0.0003179498,0.0004535723,0.0004371702,0.0004972168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004041705,"about_ca_system_score_gemma":0.0004866625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00616202,"about_ca_topic_score_gemma":0.005133424,"domain_scores_codex":[0.9997675,0.00006742054,0.00001498282,0.00004183778,0.00005169258,0.00005649649],"domain_scores_gemma":[0.9997641,0.0001224421,0.00002844798,0.00001661792,0.00003557717,0.00003263139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001143567,0.0005649069,0.03459547,0.000241097,0.0004013124,0.001516025,0.0001927502,0.9057902,0.04228908,0.002076248,0.001765859,0.009423496],"study_design_scores_gemma":[0.00005229599,0.0002191694,0.003667383,0.00001240234,0.00006072785,0.0001461996,0.0001005451,0.9884669,0.006149123,0.0004105505,0.0006902703,0.00002447513],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927012,0.0001651,0.00413017,0.0000806557,0.0000257214,0.00003021351,0.0005727637,0.0003188887,0.001975285],"genre_scores_gemma":[0.9885072,0.0001905804,0.008559802,0.00005461022,0.000005739847,0.00003800077,0.001925337,0.00006595095,0.0006528845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00616202,"threshold_uncertainty_score":0.01225233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688252598152205,"score_gpt":0.345267128919733,"score_spread":0.298384602938211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}