{"id":"W3159369840","doi":"10.3390/biom11050681","title":"mTOR Signaling in Metabolic Stress Adaptation","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Saskatchewan","funders":"","keywords":"PI3K/AKT/mTOR pathway; Biology; Cellular adaptation; Regulator; mTORC2; Signal transduction; Mechanistic target of rapamycin; TOR signaling; Adaptation (eye); Cell biology; Neuroscience; mTORC1; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003495192,0.0008098473,0.0008523181,0.00160351,0.000287372,0.0009299575,0.0006643802,0.001039539,0.003286452],"category_scores_gemma":[0.0004068261,0.0001928355,0.0004024821,0.0013768,0.0003372361,0.000898577,0.0006651889,0.001579159,0.00211302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006037652,"about_ca_system_score_gemma":0.0009656579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008292257,"about_ca_topic_score_gemma":0.00131024,"domain_scores_codex":[0.9998797,0.00001915803,0.00001953558,0.00002496609,0.00003933928,0.00001723193],"domain_scores_gemma":[0.9998813,0.00004257794,0.00001999476,0.000003090257,0.00003566359,0.0000173363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001115707,0.00005941216,0.000170474,0.01573418,0.0001059565,0.0002644879,0.00005990863,0.0005232168,0.003060499,0.005820457,0.03616646,0.9379233],"study_design_scores_gemma":[0.00001254881,0.0000742007,0.0009517678,0.002461445,0.00007884768,0.001013599,0.00003645172,0.0001105469,0.0006876788,0.001994001,0.992564,0.00001488791],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001196684,0.9984818,0.00008260173,0.0002069496,0.0001958591,0.000002657419,0.00001554937,0.000006951369,0.0008880582],"genre_scores_gemma":[0.000814322,0.99826,0.00009577967,0.000121676,0.0001595011,0.000004464934,0.00003243568,0.000001228253,0.0005105965],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003286452,"threshold_uncertainty_score":0.01099426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05978462668534072,"score_gpt":0.3016110899682324,"score_spread":0.2418264632828917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}