{"id":"W3159390542","doi":"","title":"Drug development for neurodevelopmental disorders:lessons learned from fragile X syndrome","year":2018,"lang":"en","type":"article","venue":"University of Southern Denmark Research Portal (University of Southern Denmark)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"","keywords":"Fragile X syndrome; Autism; Neurodevelopmental disorder; Metabotropic glutamate receptor 5; Neuroscience; Intellectual disability; Metabotropic glutamate receptor; Drug development; Medicine; Psychology; Autism spectrum disorder; Psychiatry; Clinical trial; Drug; Agonist; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00256659,0.0007228457,0.001282279,0.000910315,0.0003226877,0.001259511,0.0006152874,0.001397714,0.003761456],"category_scores_gemma":[0.002990128,0.0002346281,0.0005794283,0.0005849046,0.001054309,0.002894476,0.0008950589,0.003306451,0.001018561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008568897,"about_ca_system_score_gemma":0.001280605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320643,"about_ca_topic_score_gemma":0.003403399,"domain_scores_codex":[0.9995347,0.0001566599,0.00005669381,0.0000722841,0.0001260079,0.0000535489],"domain_scores_gemma":[0.998142,0.001200632,0.0001186979,0.00007340965,0.0003088125,0.0001564835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003440357,0.0002239484,0.0006681072,0.006673923,0.0001610243,0.001197089,0.0004006749,0.001295418,0.004798959,0.02350764,0.04468641,0.9160427],"study_design_scores_gemma":[0.0002797689,0.001455971,0.001655676,0.004903199,0.0002619595,0.003132188,0.000425271,0.0007132211,0.00354833,0.02939263,0.9541607,0.00007105341],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004503363,0.965479,0.002847974,0.01976147,0.001145235,0.00003164296,0.00011595,0.00009108338,0.006024227],"genre_scores_gemma":[0.01795169,0.9694214,0.003358934,0.005936738,0.0008949769,0.00003274613,0.00009047087,0.00002260959,0.00229048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003761456,"threshold_uncertainty_score":0.01357359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03299551799264887,"score_gpt":0.2578481895376534,"score_spread":0.2248526715450045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}