{"id":"W3159397515","doi":"10.2139/ssrn.3701260","title":"Partial Suppression of Ca <sub>v</sub>2.1 Function Prevents Synaptic and Behavioral Impairments in Alzheimer's Disease Models","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"Neuroscience; Function (biology); Psychology; Disease; Medicine; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002858448,0.001009678,0.001056152,0.000675211,0.0003974349,0.0005620418,0.001130151,0.0009981057,0.004165857],"category_scores_gemma":[0.0002387806,0.0003558253,0.0005492542,0.000437334,0.0009258403,0.0007043761,0.0002998101,0.00256736,0.002053593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000779118,"about_ca_system_score_gemma":0.001104999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003346609,"about_ca_topic_score_gemma":0.005749265,"domain_scores_codex":[0.9996819,0.00003376973,0.00003482342,0.00004930693,0.00004601714,0.0001542401],"domain_scores_gemma":[0.9996853,0.00003008982,0.00006645508,0.00003509144,0.00002485908,0.0001581823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004214011,0.0006585554,0.0002110839,0.0001557246,0.00004538062,0.0002135712,0.00007907089,0.0002361472,0.9888079,0.0007879508,0.0009507869,0.003639766],"study_design_scores_gemma":[0.0007517348,0.002808588,0.004690383,0.00004838085,0.00008941185,0.0003917426,0.000210477,0.001348855,0.9832661,0.0004568303,0.005906351,0.00003119529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872352,0.001142744,0.00185062,0.0005139891,0.0002079459,0.0001135443,0.003766632,0.0006744349,0.004494861],"genre_scores_gemma":[0.9803948,0.001305736,0.003619074,0.0002252323,0.00007630225,0.0003674184,0.002884789,0.0002225467,0.01090421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004165857,"threshold_uncertainty_score":0.01393616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03156785747229449,"score_gpt":0.3071162803521964,"score_spread":0.2755484228799019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}