{"id":"W3159405380","doi":"10.1085/jgp.202012850","title":"Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1","year":2021,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; European Research Council; Natural Sciences and Engineering Research Council of Canada; Compute Canada; Canadian Institutes of Health Research; Linköpings Universitet; Svenska Sällskapet för Medicinsk Forskning; Horizon 2020 Framework Programme; Canada Research Chairs; National Institutes of Health; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Killam Trusts; Alberta Innovates - Health Solutions","keywords":"Polyunsaturated fatty acid; Chemistry; Biophysics; Potassium channel; Amphiphile; Ion channel; Selectivity; Hydrophobic effect; Fatty acid; Biochemistry; Receptor; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001185107,0.0002447083,0.0002884653,0.000167058,0.0003465343,0.0001747122,0.0003026198,0.0003144002,0.001993111],"category_scores_gemma":[0.0003168741,0.0001519073,0.0002602172,0.0001225138,0.0001910333,0.000244108,0.0003238089,0.0003109726,0.0005864635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003381677,"about_ca_system_score_gemma":0.0002561998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001836933,"about_ca_topic_score_gemma":0.001856677,"domain_scores_codex":[0.9999261,0.000009053116,0.000003634776,0.0000230537,0.00002046553,0.00001770305],"domain_scores_gemma":[0.999872,0.00003375431,0.00003588125,0.00001330537,0.00002161125,0.00002356188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009316921,0.00006235112,0.007162007,0.0001770843,0.00003906003,0.0004295031,0.00009790199,0.004131606,0.9769607,0.001225029,0.0002429211,0.008540093],"study_design_scores_gemma":[0.0001578106,0.0003904099,0.0295341,0.00004815618,0.0001001602,0.0006854528,0.0002036907,0.05502729,0.9076936,0.001705746,0.004373124,0.00008054658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921319,0.0005772674,0.006012108,0.00008885018,0.0000136693,0.00001594014,0.0002259698,0.00006959328,0.0008646749],"genre_scores_gemma":[0.9948443,0.0002129154,0.004308234,0.0000280051,0.00000302195,0.00001228016,0.0001781796,0.00000892348,0.0004041131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993111,"threshold_uncertainty_score":0.006667674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781762183383269,"score_gpt":0.2601766178787431,"score_spread":0.2423589960449104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}