{"id":"W3159440343","doi":"10.3390/ijms22094699","title":"Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; University of Alberta","funders":"University of Illinois at Urbana-Champaign; Hudson Institute of Medical Research; Sigrid Juséliuksen Säätiö; Fukuoka University; Academy of Finland; University of Alberta; Women and Children's Health Research Institute; Washington University in St. Louis; U.S. Department of Defense","keywords":"Apoptosis; Cell culture; Cancer research; Tumor necrosis factor alpha; Cytotoxic T cell; Activator (genetics); Necrosis; Caspase; Biology; Cell; Viability assay; Granulosa cell; Programmed cell death; Chemistry; In vitro; Molecular biology; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139094,0.0002371405,0.0003649877,0.000181314,0.00007350359,0.0002607074,0.0001500811,0.0001399057,0.0005417585],"category_scores_gemma":[0.0001620928,0.00008898541,0.0003581276,0.0001908344,0.0001271378,0.0001448781,0.0001288729,0.0003561499,0.0001812265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00031496,"about_ca_system_score_gemma":0.0002387558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659515,"about_ca_topic_score_gemma":0.0009998236,"domain_scores_codex":[0.9998739,0.00003621585,0.00001280778,0.00001984034,0.00003597133,0.00002127133],"domain_scores_gemma":[0.9999181,0.00002928446,0.00002250726,0.000009996628,0.000009945364,0.00001018579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006870321,0.0002531391,0.001551643,0.0002562203,0.00004273536,0.0003959246,0.00006660057,0.006897503,0.9771286,0.0002906381,0.000234498,0.01219544],"study_design_scores_gemma":[0.00006739327,0.002043252,0.002710597,0.00001549065,0.00004593845,0.0005632162,0.00003407159,0.01131916,0.980301,0.0000839447,0.002808673,0.000007273692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908896,0.003952545,0.003452442,0.0000761995,0.00003266553,0.00004875866,0.0002489414,0.00004683403,0.00125185],"genre_scores_gemma":[0.995661,0.001384083,0.001992346,0.00002187518,0.000006528273,0.00002144668,0.0002247881,0.000005063611,0.0006828151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007659515,"threshold_uncertainty_score":0.002285242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007586612094885097,"score_gpt":0.224216468190752,"score_spread":0.2166298560958669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}