{"id":"W3159489238","doi":"10.1038/s41467-021-22750-8","title":"Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Kay Kendall Leukaemia Fund; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Haploinsufficiency; Homeobox; Evasion (ethics); Myeloid leukemia; Suppressor; Cancer research; Gene; Myeloid; Apoptosis; Cell biology; Leukemia; Biology; Immunology; Genetics; Gene expression; Immune system; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155182,0.0002054854,0.000204842,0.0002071889,0.0001160858,0.0002551952,0.0001205261,0.0001738829,0.001160436],"category_scores_gemma":[0.00009291165,0.00007631621,0.00009122585,0.0001194162,0.0002144569,0.0000966743,0.0002068761,0.0004750573,0.0001612005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766445,"about_ca_system_score_gemma":0.000161819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002749602,"about_ca_topic_score_gemma":0.0008527028,"domain_scores_codex":[0.9998657,0.00001876563,0.00001529531,0.00002949067,0.00003894629,0.00003186595],"domain_scores_gemma":[0.9998996,0.00001939466,0.00002985878,0.00001169072,0.000006584343,0.00003297041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005796907,0.00002176523,0.0004173622,0.00001598635,0.000003565652,0.00008911257,0.0000102131,0.00006811276,0.9973552,0.0001858715,0.00006686557,0.001707837],"study_design_scores_gemma":[0.00001915991,0.0002770651,0.006912653,0.000005481621,0.00001007989,0.0007932629,0.00003885819,0.001222351,0.9874569,0.00009249998,0.003168813,0.000002864006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966038,0.000501535,0.001586753,0.00008321791,0.00001645602,0.00001536733,0.0001848014,0.00009007024,0.000917863],"genre_scores_gemma":[0.9978057,0.0001756368,0.0007788897,0.00003107153,0.000003928669,0.000009441966,0.0001900478,0.000009883853,0.0009955009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160436,"threshold_uncertainty_score":0.003882051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0293110581156517,"score_gpt":0.3316865969205472,"score_spread":0.3023755388048955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}