{"id":"W3159489238","doi":"10.1038/s41467-021-22750-8","title":"Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Kay Kendall Leukaemia Fund; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Haploinsufficiency; Homeobox; Evasion (ethics); Myeloid leukemia; Suppressor; Cancer research; Gene; Myeloid; Apoptosis; Cell biology; Leukemia; Biology; Immunology; Genetics; Gene expression; Immune system; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007282273,0.0003892075,0.000602107,0.0005554369,0.0007880063,0.0001428634,0.00210904,0.0005929694,0.0002651743],"category_scores_gemma":[0.002729428,0.0003675581,0.0002474675,0.002567908,0.0002932685,0.0002421273,0.002202711,0.003496009,0.0003348716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001893197,"about_ca_system_score_gemma":0.003033203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001922931,"about_ca_topic_score_gemma":0.0003786728,"domain_scores_codex":[0.9963301,0.0004687143,0.0006205097,0.0007560995,0.0009933092,0.0008312764],"domain_scores_gemma":[0.9916869,0.0007427548,0.0001554096,0.005191827,0.001608648,0.0006144556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000285362,0.001366093,0.002198529,0.0001878576,0.0002987758,0.0001445053,0.002082727,0.00008538958,0.8404871,0.004684643,0.1415336,0.006645405],"study_design_scores_gemma":[0.002995831,0.000443271,0.02110266,0.0003362949,0.0003293354,0.0004551718,0.00364655,0.001386527,0.4252348,0.0001642495,0.5430197,0.0008857034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290286,0.009349312,0.0001916283,0.04844955,0.0003979522,0.001387502,0.0001610129,0.0003487017,0.01068572],"genre_scores_gemma":[0.9628766,0.001529382,0.02472468,0.005399636,0.0002176007,0.0002756776,0.0007865227,0.00009864192,0.004091294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4152524,"threshold_uncertainty_score":0.9998776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0293110581156517,"score_gpt":0.3316865969205472,"score_spread":0.3023755388048955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}