{"id":"W3159493688","doi":"10.1016/j.csbj.2021.03.040","title":"Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement","year":2021,"lang":"en","type":"article","venue":"Computational and Structural Biotechnology Journal","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Space Agency","keywords":"Microbiome; Roseburia; Spaceflight; Faecalibacterium prausnitzii; Biology; Human microbiome; Gut flora; Prebiotic; Inflammation; Dysbiosis; Calprotectin; Human Microbiome Project; Physiology; Immunology; Bioinformatics; Lactobacillus; Bacteria; Medicine; Inflammatory bowel disease; Genetics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423438,0.0001247181,0.0003046054,0.0001802232,0.0001387143,0.00001988729,0.00009041058,0.0001873086,0.00009725668],"category_scores_gemma":[0.00006197196,0.00008492844,0.00007324365,0.0003088318,0.000175077,0.00003957988,0.00007660328,0.0003606131,8.579287e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009432651,"about_ca_system_score_gemma":0.0001034263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001400617,"about_ca_topic_score_gemma":0.00002834579,"domain_scores_codex":[0.9988928,0.0001363567,0.0004749734,0.0001896952,0.0001536547,0.0001525504],"domain_scores_gemma":[0.9993559,0.00006745641,0.0002453333,0.0001424029,0.0001409242,0.00004801915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006206593,0.00004190498,0.01988112,0.00001340528,0.0001396864,0.000022647,0.0001024313,0.0001472909,0.9742933,0.001047953,0.000436468,0.003811713],"study_design_scores_gemma":[0.002612444,0.0004120626,0.585849,0.0001499485,0.0001067013,0.002782169,0.0002954301,0.003219524,0.4003626,0.003818653,0.0002096631,0.0001818187],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752059,0.0007290536,0.0007696165,0.02291202,0.0001662356,0.0001699439,0.00001747789,0.00001050096,0.00001928066],"genre_scores_gemma":[0.9969932,0.00003430732,0.002412436,0.0003574203,0.0000354746,0.000004225645,0.000102295,0.00000511177,0.0000555589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5739307,"threshold_uncertainty_score":0.3463281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009101903087792322,"score_gpt":0.2758782349485015,"score_spread":0.2667763318607092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}