{"id":"W3159554053","doi":"10.2337/db20-1295","title":"MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Japan Society for the Promotion of Science; National Center for Global Health and Medicine; Nihon University","keywords":"Exocytosis; Glucose homeostasis; Insulin; Internal medicine; Endocrinology; Homeostasis; Biology; Diabetes mellitus; MAPK/ERK pathway; Glucose uptake; Insulin oscillation; Signal transduction; Cell biology; Medicine; Insulin resistance; Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249629,0.0004533121,0.000220146,0.0002191842,0.0001323253,0.0003887941,0.000217628,0.0001721028,0.001242003],"category_scores_gemma":[0.00006730904,0.0001256204,0.0001975141,0.0001212799,0.000221868,0.0002804205,0.0002570437,0.0006296998,0.0002824619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724995,"about_ca_system_score_gemma":0.0001295469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001677137,"about_ca_topic_score_gemma":0.0002927528,"domain_scores_codex":[0.9998901,0.00001521356,0.000008842728,0.00002785288,0.0000233541,0.00003467788],"domain_scores_gemma":[0.9999423,0.00000540157,0.00001716946,0.000007223647,0.000005633642,0.00002225191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002120551,0.00002984643,0.000340886,0.00003536065,0.000006079332,0.00003525314,0.000007090405,0.00005821414,0.9974528,0.0002108243,0.00003218571,0.0015795],"study_design_scores_gemma":[0.00002813006,0.0001881269,0.009653719,0.00001085222,0.00003079566,0.0003778689,0.0000424352,0.00134664,0.9847916,0.0002238663,0.00329747,0.000008353039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940605,0.001550679,0.002800311,0.0001057394,0.00002984243,0.000008116397,0.0002848092,0.00007444677,0.001085626],"genre_scores_gemma":[0.9952837,0.001107467,0.001739253,0.00004722034,0.00000844461,0.00001077534,0.0002908743,0.00001607767,0.001496216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242003,"threshold_uncertainty_score":0.004154921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008288046629188,"score_gpt":0.2285395027006857,"score_spread":0.2184566222343939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}