{"id":"W3159572149","doi":"10.1182/blood.2020010463","title":"TLR8 gain of function: a tall surprise","year":2021,"lang":"en","type":"letter","venue":"Blood","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Gain of function; Function (biology); Medicine; Biology; Cell biology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003144593,0.0007609026,0.001463481,0.0004671793,0.002435214,0.003605936,0.001395576,0.02475523,0.00586902],"category_scores_gemma":[0.0134145,0.0004126081,0.0008021959,0.0002801645,0.003672755,0.003426087,0.001976612,0.03792504,0.004835702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002833058,"about_ca_system_score_gemma":0.002429055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001960377,"about_ca_topic_score_gemma":0.002937231,"domain_scores_codex":[0.9979537,0.0006382217,0.0001385302,0.0002865582,0.0007215196,0.0002615151],"domain_scores_gemma":[0.9945326,0.003162407,0.0001996851,0.0002124072,0.0008297177,0.001063209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001110387,0.00003675744,0.0002069834,0.00003598741,0.00001481279,0.0006725767,0.00004931954,0.00004119788,0.0003233472,0.003246463,0.9803612,0.0149002],"study_design_scores_gemma":[0.0002151667,0.0001250477,0.0007132565,0.0002102341,0.00003048544,0.00110352,0.0003552924,0.0003639936,0.0006511409,0.02279207,0.9733766,0.00006312263],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002866785,0.00418669,0.0001263135,0.9680972,0.025096,0.000004412779,0.00003202917,0.00003645511,0.002134213],"genre_scores_gemma":[0.006262411,0.004708595,0.0003198952,0.8831488,0.09800304,0.00002758027,0.00003319377,0.00003599675,0.007460414],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02475523,"threshold_uncertainty_score":0.02055532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069601934426049,"score_gpt":0.1997835176172399,"score_spread":0.1890874982729794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}