{"id":"W3159593160","doi":"10.1038/s41590-021-00925-1","title":"A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Stem cell; Haematopoiesis; Biology; Hematopoietic stem cell; Cell biology; Regeneration (biology); Immunology; Epigenetics; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001815309,0.0002696227,0.0005564561,0.0002064676,0.0002083964,0.00001952809,0.0003500273,0.0009961935,0.001691167],"category_scores_gemma":[0.00005206868,0.0002517184,0.000181126,0.0003445173,0.0001636313,0.0001070679,0.0002492472,0.001106801,0.0003787439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009301421,"about_ca_system_score_gemma":0.0001052369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006131059,"about_ca_topic_score_gemma":0.0001219601,"domain_scores_codex":[0.99778,0.0006557834,0.0005737964,0.0005097566,0.00006954739,0.0004111219],"domain_scores_gemma":[0.9982626,0.0001491211,0.0002613085,0.0007177527,0.0005831116,0.00002610865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000394372,0.0002990783,0.0003396981,0.00006285983,0.0004673996,0.00002732013,0.001099893,0.0000160153,0.9770811,0.004135021,0.01578891,0.0002882852],"study_design_scores_gemma":[0.001045024,0.0003809726,0.002544033,0.0001294694,0.00005152965,0.0001151012,0.001282935,7.762368e-7,0.9685135,0.00005571896,0.02565495,0.0002259493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732885,0.01681671,0.00006361691,0.0006386895,0.007009453,0.0003560481,0.00005477586,0.00008203809,0.001690169],"genre_scores_gemma":[0.9497475,0.00008619705,0.00003401891,0.0002707601,0.0000361088,0.00004389329,0.0002926302,0.00002842582,0.04946046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04777029,"threshold_uncertainty_score":0.9999935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196139280076841,"score_gpt":0.2549001419113305,"score_spread":0.2429387491105621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}