{"id":"W3159623463","doi":"10.1039/d1bm00273b","title":"Hydrogel based lipid-oligonucleotides: a new route to self-delivery of therapeutic sequences","year":2021,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Inserm Transfert; Agence Nationale de la Recherche","keywords":"Oligonucleotide; Chemistry; Conjugate; Computational biology; Biophysics; Biochemistry; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003907611,0.0001493869,0.0002101837,0.00009895735,0.000107496,0.00007046974,0.0003627696,0.00007558973,0.00000815258],"category_scores_gemma":[0.00008753543,0.000124339,0.00008601391,0.0006082758,0.0002502193,0.00001095989,0.0001600309,0.00001265465,0.000005897038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002597174,"about_ca_system_score_gemma":0.0006903628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006330741,"about_ca_topic_score_gemma":0.00001854023,"domain_scores_codex":[0.9986287,0.0000455798,0.0002730804,0.0005144477,0.0002585675,0.0002796002],"domain_scores_gemma":[0.9990135,0.000009935545,0.0001233014,0.000474153,0.0002362408,0.0001428193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002509169,0.00004045345,0.0002371152,0.00001055934,0.00001542896,0.000003764521,0.00001958624,0.000009652764,0.9984011,0.00004278365,0.00009948761,0.001094987],"study_design_scores_gemma":[0.0001154143,0.0001447297,0.0004757365,0.00003340425,0.00002241184,0.00001236027,0.00003351221,0.00006758595,0.9959369,0.00008154057,0.002903837,0.0001725282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997966,0.0001402433,0.001137307,0.0002500727,0.0001633238,0.00009989829,0.00002680725,0.00006252087,0.0001538307],"genre_scores_gemma":[0.954783,0.00005712697,0.04429482,0.0006244032,0.0001219635,0.0000032412,0.00001546641,0.000009802761,0.00009023933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04318306,"threshold_uncertainty_score":0.5070399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467043385591593,"score_gpt":0.2822541661049216,"score_spread":0.2675837322490057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}