{"id":"W3159628964","doi":"10.1016/j.celrep.2021.109036","title":"4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; McGill University Health Centre; Canadian Institutes of Health Research; Simons Foundation Autism Research Initiative; Canada First Research Excellence Fund; McGill University","keywords":"mTORC1; Cerebellum; Neuroscience; Tensin; TSC1; Translation (biology); Biology; PI3K/AKT/mTOR pathway; Chemistry; Cell biology; PTEN; Signal transduction; Messenger RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839654,0.000177516,0.0001955014,0.00004796983,0.00005453538,0.00004045006,0.00006726227,0.0002229703,0.0002475869],"category_scores_gemma":[0.00002733209,0.0001943823,0.0001538574,0.00007083693,0.00004059125,0.000006529564,0.00004336336,0.00009546163,0.00001339224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002757601,"about_ca_system_score_gemma":0.0002556456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001192137,"about_ca_topic_score_gemma":0.0002127225,"domain_scores_codex":[0.9983724,0.00008936124,0.0004850988,0.0005319972,0.0002716619,0.0002494213],"domain_scores_gemma":[0.9990739,0.00001156654,0.0001788676,0.0004927572,0.00006979396,0.0001731271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007118545,0.0002033661,0.003490718,0.00002069939,0.00001178765,0.00115741,0.00004608821,0.0006208179,0.9910142,0.000002761407,0.0003160232,0.003044932],"study_design_scores_gemma":[0.001125272,0.00004830243,0.01794109,0.000009914445,0.00005855512,0.00009602354,0.0000622956,0.0001536609,0.9688234,0.00003275984,0.01138296,0.0002657656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993497,0.0008399936,0.001033997,0.0001431388,0.0006792953,0.0003042871,0.00001927982,0.00001907453,0.003463979],"genre_scores_gemma":[0.9926736,0.00007274779,0.0001703524,0.0002877889,0.0001118978,0.00002166169,0.0003679005,0.00002699153,0.006267082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02219081,"threshold_uncertainty_score":0.7926679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00877427094651565,"score_gpt":0.2298108137608723,"score_spread":0.2210365428143566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}