{"id":"W3159637870","doi":"10.1242/dev.192054","title":"MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Sherbrooke","funders":"European Social Fund; Medical Research Council; National Institutes of Health; Neuron Nadační Fond Na Podporu Vědy; Masarykova Univerzita; KWF Kankerbestrijding; Vetenskapsrådet; Karolinska Institutet; Universiteit van Amsterdam; Grantová Agentura České Republiky; Cancerfonden; New York Stem Cell Foundation; Stiftelsen för Strategisk Forskning; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIHR Cambridge Biomedical Research Centre; Boston Children's Hospital; European Commission; Stiftelsen för Strategisk Forskning; Hjärnfonden","keywords":"Choroid plexus; Wnt signaling pathway; Biology; WNT5A; Cell biology; Fourth ventricle; Cerebrospinal fluid; Ventricle; Morphogenesis; Epithelium; Beta-catenin; Anatomy; Cerebral ventricle; Embryonic stem cell; Internal medicine; Signal transduction; Endocrinology; Gene; Central nervous system; Genetics; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000243093,0.0001463695,0.000160589,0.00004482254,0.0001029155,0.00001389169,0.0001152302,0.0001071548,0.00007563632],"category_scores_gemma":[0.00006745585,0.0001502294,0.00006571289,0.0001454334,0.00002560186,0.00000273744,0.0001638004,0.00004686515,0.00001906757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003938392,"about_ca_system_score_gemma":0.0005133663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002494649,"about_ca_topic_score_gemma":0.00005195524,"domain_scores_codex":[0.9987651,0.00003838989,0.0004084552,0.000326633,0.0002274206,0.0002340395],"domain_scores_gemma":[0.9993349,0.00001036975,0.000109276,0.0002632003,0.0001968664,0.00008534822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002804805,0.0001654209,0.01104337,0.00005083291,0.0001702975,0.000008322932,0.000709302,0.0001373591,0.9202608,0.00006923964,0.0002928433,0.06706411],"study_design_scores_gemma":[0.0002880608,0.00002576944,0.05693305,0.00001549538,0.000006233375,0.000001980951,0.00005908876,0.00001500042,0.7723914,0.00004355883,0.1700666,0.0001537606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910516,0.002702681,0.004785754,0.00003670275,0.0001513447,0.0001079063,0.000003648307,0.00001343986,0.001146887],"genre_scores_gemma":[0.90943,0.000159242,0.08864968,0.00004577388,0.00005940094,0.00002101241,0.0002630005,0.00001977818,0.001352064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1697737,"threshold_uncertainty_score":0.6126179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440446299347284,"score_gpt":0.2448521566675116,"score_spread":0.2304476936740388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}